Organization of motor pools depends on the combined function of N-cadherin and type II cadherins
Organization of motor pools depends on the combined function of N-cadherin and type II cadherins
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DOI：
10.1242/dev.180422
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发表时间：
2019-07-01
期刊：
影响因子：
4.6
通讯作者：
Zampieril, Niccolo
中科院分区：
文献类型：
--
作者：
Dewitz, Carola;Duan, Xin;Zampieril, Niccolo
I型和II型经典钙粘蛋白构成了一个家庭的细胞粘附分子表达在复杂的组合配置文件在神经系统中，这表明钙粘蛋白代码实现特定的粘合剂识别事件，控制神经回路的发展。在脊髓中，经典钙粘蛋白在分子水平上将运动神经元亚型的位置组织定义为称为运动池的离散核结构。然而，在定义运动神经元的空间组织的家庭的不同成员的角色和贡献还不清楚。通过将小鼠遗传学与定量位置分析相结合，我们发现运动神经元组织成池依赖于II型钙粘蛋白。然而，II型钙粘蛋白功能并不严格反映在分子水平上结合特异性所产生的预测，而是依赖于N-钙粘蛋白，一种I型钙粘蛋白，其消除需要揭示II型贡献。
Type I and type II classical cadherins constitute a family of cell adhesion molecules expressed in complex combinatorial profiles in the nervous system, suggesting that a cadherin code implements specific adhesive recognition events that control the development of neural circuits. In the spinal cord, classical cadherins define at a molecular level the positional organization of motor neuron subtypes into discrete nuclear structures termed motor pools. However, the roles and contributions of different members of the family in defining motor neuron spatial organization are not yet clear. By combining mouse genetics with quantitative positional analysis, we found that motor neuron organization into pools depends on type II cadherins. Type II cadherin function, however, does not strictly reflect the predictions arising from binding specificities at a molecular level, but instead relies on N-cadherin, a type I cadherin whose elimination is required to reveal type II contributions.