Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population
Functional CLOCK gene rs1554483 G/C polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese population
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DOI：
10.1177/0300060513476430
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发表时间：
2013-04-01
影响因子：
1.6
通讯作者：
Zhang, Xue-Mei
中科院分区：
文献类型：
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作者：
Chen, Qian;Huang, Chang-Quan;Zhang, Xue-Mei
目的：探讨中国人昼夜节律运动输出周期卡普特（CLOCK）基因rs1554483 G/C多态性与阿尔茨海默病易感性之间的关系。方法：本病例对照研究采用聚合酶链反应限制性片段长度确定载脂蛋白E（APOE）和CLOCK rs1554483 G/C基因型 结果：对无关的阿尔茨海默病患者 (n = 130) 和健康对照 (n = 188) 进行了分析，以了解 CLOCK 基因 rs1554483 G/C 多态性与阿尔茨海默病易感性之间的关联。在整个样本和 APOE epsilon 4 同种型非携带者中，阿尔茨海默病患者中 CLOCK 基因 rs1554483 G 等位基因携带者的患病率显着高于对照组。在APOE epsilon 4携带者中，CLOCK rs1554483 G等位基因携带者的患病率在阿尔茨海默病患者和对照之间没有显着差异。结论：在APOE epsilon 4非携带者中，而不是APOE epsilon 4携带者中，CLOCK rs1554483 G等位基因与阿尔茨海默病易感性增加相关。
Objective: To examine the association between the circadian locomotor output cycles kaput (CLOCK) gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease in Chinese people.Methods: This case-control study determined apolipoprotein E (APOE) and CLOCK rs1554483 G/C genotypes using polymerase chain reaction restriction fragment length polymorphism.Results: Unrelated patients with Alzheimer's disease (n = 130) and healthy controls (n = 188) were analysed for an association between the CLOCK gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease. In the whole sample and in APOE epsilon 4 isoform noncarriers, the prevalence of CLOCK gene rs1554483 G allele carriers was significantly higher in patients with Alzheimer's disease than in controls. Among APOE epsilon 4 carriers, the prevalence of CLOCK rs1554483 G allele carriers was not significantly different between patients with Alzheimer's disease and controls.Conclusion: Among APOE epsilon 4 noncarriers, but not APOE epsilon 4 carriers, the CLOCK rs1554483 G allele was associated with increased susceptibility to Alzheimer's disease.