Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats.
Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats.
复制标题
Dahl 大鼠第 3 号染色体上的两个血压/心脏质量数量性状位点。
DOI：
10.1007/s003359900954
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Rapp,JP
中科院分区：
文献类型：
--
作者：
Cicila,GT;Choi,C;Dene,H;Lee,SJ;Rapp,JP
Interval mapping was used to identify putative quantitative trait loci (QTL) for blood pressure and cardiac mass on Chromosome (Chr) 3 in F1(S × R) × S population of 150 rats raised on an 8% NaCl diet. Two genetic markers 95.7 cM apart,D3Wox3andD3Mco5(tightly linked toEdn3), showed ``suggestive'' linkage to blood pressure (LOD = 2.0 and 1.8 respectively). In addition,D3Wox3showed ``suggestive'' linkage to heart weight (LOD = 2.5), andD3Mco5showed ``suggestive'' linkage to body weight–adjusted heart weight (LOD = 2.1). Congenic rats (designated S.R-Edn3) were constructed by introgressing the R-ratEdn3allele (and flanking loci) into the S strain. On a 2% NaCl diet, S.R-Edn3 rats had lower blood pressure (21.4 mm Hg,P= 0.0005) and heart weight (59 mg,P= 0.0038) compared with S rats, confirming the existence of a blood pressure QTL on Chr 3 nearEdn3even though QTL linkage analysis of blood pressure did not achieve stringent statistical criteria for significance. The results of the congenic experiment and the large distance between the two putative QTL suggest the presence of at least two independent blood pressure/cardiac mass QTL detectable on Chr 3 in the Dahl rat model of genetic hypertension.
