The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics.
The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics.
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DOI：
10.3389/fchem.2021.674786
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发表时间：
2021
影响因子：
5.5
通讯作者：
Cucchiarini M
中科院分区：
文献类型：
--
作者：
Eftekhari A;Arjmand A;Asheghvatan A;Švajdlenková H;Šauša O;Abiyev H;Ahmadian E;Smutok O;Khalilov R;Kavetskyy T;Cucchiarini M
肝纤维化是全世界由于慢性肝损伤导致发病率和死亡率的主要原因，并导致肝硬化、肝癌和肝衰竭。迄今为止，对于肝纤维化患者没有有效和特异性的治疗。由于它们的各种优点，如生物相容性，成像对比能力，改善的组织渗透性和超顺磁性，磁性纳米粒子在包括纤维化在内的各种肝脏疾病的诊断和治疗中具有巨大的潜力。本文就肝纤维化的分子机制、影响因素以及磁性纳米粒子的治疗作用作一综述。还讨论了诊断肝纤维化的新策略，总结了磁性纳米颗粒从实验室到床边的转化应用的挑战和前景。
Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic liver damage and leading to cirrhosis, liver cancer, and liver failure. To date, there is no effective and specific therapy for patients with hepatic fibrosis. As a result of their various advantages such as biocompatibility, imaging contrast ability, improved tissue penetration, and superparamagnetic properties, magnetic nanoparticles have a great potential for diagnosis and therapy in various liver diseases including fibrosis. In this review, we focus on the molecular mechanisms and important factors for hepatic fibrosis and on potential magnetic nanoparticles-based therapeutics. New strategies for the diagnosis of liver fibrosis are also discussed, with a summary of the challenges and perspectives in the translational application of magnetic nanoparticles from bench to bedside.