Stimulus-induced intercolumnar synchronization of neuronal activity in rat barrel cortex: a laminar analysis.
Stimulus-induced intercolumnar synchronization of neuronal activity in rat barrel cortex: a laminar analysis.
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刺激诱导大鼠桶状皮层神经元活动的柱间同步：层流分析。
DOI：
10.1152/jn.01272.2003
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发表时间：
2004
影响因子：
2.5
通讯作者：
Alloway,KevinD
中科院分区：
文献类型：
--
作者：
Zhang,Mengliang;Alloway,KevinD
我们使用交叉相关分析来表征异氟烷麻醉大鼠的初级躯体感觉皮层桶刺激诱导的神经元活动的协调。在每次试验中，多个晶须同时在对应于2、5、8或11 Hz的频率下偏转。在我们检查的476个神经元对中，342个（71.8%）显示出超过99.9%置信限的同步活动的显著峰值。这些功能关联的发生率和强度在不同的皮质层中各不相同。只有52.9%的神经元对在第四层显示同步反应，而84.1%的颗粒下神经元对在晶须刺激过程中同步。神经元同步是最强的颗粒下层，最弱的第四层，并根据不同的柱状配置的神经元对。因此，相关系数最大的神经元对在同一晶须桶行，但最小的神经元在不同的行和弧。自发活动在颗粒下层也同步到一个更大的程度比其他层。虽然颗粒下神经元对每个刺激频率的同步响应量相似，颗粒和颗粒上神经元同步主要是在2或5 Hz的刺激。这些结果与先前的研究一致，表明颗粒下神经元具有促进同步活动的内在特性，并且它们表明神经元同步在将感觉信息传递到其他皮层或皮层下脑区域中起着重要作用。
We used cross-correlation analysis to characterize the coordination of stimulus-induced neuronal activity in the primary somatosensory barrel cortex of isoflurane-anesthetized rats. On each trial, multiple whiskers were simultaneously deflected at frequencies that corresponded to 2, 5, 8, or 11 Hz. Among 476 neuron pairs that we examined, 342 (71.8%) displayed significant peaks of synchronized activity that exceeded the 99.9% confidence limits. The incidence and strength of these functional associations varied across different cortical layers. Only 52.9% of neuron pairs in layer IV displayed synchronized responses, whereas 84.1% of the infragranular neuron pairs were synchronized during whisker stimulation. Neuronal synchronization was strongest in the infragranular layers, weakest in layer IV, and varied according to the columnar configuration of the neuron pairs. Thus correlation coefficients were largest for neuron pairs in the same whisker barrel row but were smallest for neurons in different rows and arcs. Spontaneous activity in the infragranular layers was also synchronized to a greater degree than in the other layers. Although infragranular neuron pairs displayed similar amounts of synchronization in response to each stimulus frequency, granular and supragranular neurons were synchronized mainly during stimulation at 2 or 5 Hz. These results are consistent with previous studies indicating that infragranular neurons have intrinsic properties that facilitate synchronized activity, and they suggest that neuronal synchronization plays an important role in transmitting sensory information to other cortical or subcortical brain regions.