CHROMOSOME BREAKAGE AND SISTER CHROMATID EXCHANGE ANALYSIS IN COMPUTER OPERATORS.
CHROMOSOME BREAKAGE AND SISTER CHROMATID EXCHANGE ANALYSIS IN COMPUTER OPERATORS.
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计算机操作员的染色体断裂和姐妹染色单体交换分析。
DOI：
10.1080/10934528709375383
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
Jenkins,BonnieB
中科院分区：
文献类型：
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作者：
Butler,MerlinG;Yost,Jennifer;Jenkins,BonnieB
染色体断裂分析与丝裂霉素C（MMC）和姐妹染色单体交换（SCE），获得了10个计算机操作员与计算机接触至少3小时，每天4年和10个对照组相匹配的年龄和个人生活方式。在丝裂霉素C（20或50 ng/ml-最终浓度）中生长48和/或96小时的细胞中，两组间染色单体和染色体畸变总数无差异。每个人大约30个细胞中每个细胞的SCE平均数，计算机操作员为6.4±1.1（平均值±标准差），对照组为9.2 ± 1.6。这种差异是显著的（p <0.001）。计算机操作者的复制指数显著高于对照组（p<0.01）。SCE的数量似乎不受电脑暴露的年数的影响。将需要更多的研究，更大的样本量，以确定是否存在显着差异，在细胞动力学和姐妹染色单体交换的个人雇用为计算机操作员。
Chromosome breakage analysis with Mitomycin C (MMC) and sister chromatid exchanges (SCE) were obtained on 10 computer operators with computer exposure for a minimum of 3 hours per day for 4 years and 10 control subjects matched for age and personal lifestyle. No difference was found between the two groups in the total number of chromatid and chromosome aberrations in cells grown at 48 and/or 96 hours in Mitomycin C (20 or 50 ng/ml‐final concentration). The average number of SCE per cell in approximately 30 cells from each person was 6.4±1.1 (mean ± standard deviation) for the computer operators and 9.2 ± 1.6 for the controls. This difference was significant (p <.001). The replicative index was significantly higher (p<.01) in computer operators than in control subjects. The number of SCE appeared not to be influenced by the years of computer exposure. Additional studies with larger sample sizes will be needed to identify if significant differences exist in cell kinetics and sister chromatid exchanges in individuals employed as computer operators.