Technical performance evaluation of a human brain PET/MRI system
Technical performance evaluation of a human brain PET/MRI system
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DOI：
10.1007/s00330-012-2415-4
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发表时间：
2012-08-01
影响因子：
5.9
通讯作者：
Pichler, Bernd J.
中科院分区：
文献类型：
--
作者：
Kolb, Armin;Wehrl, Hans F.;Pichler, Bernd J.
人脑PET/MRI系统的技术性能评估：磁场兼容正电子发射断层扫描（PET）插入物基于雪崩光电二极管（APD）阵列，与氧硅酸镥（LSO）晶体耦合，并滑入稍微修改的临床3-T MRI系统。通过精心设计硬件，使两种成像技术之间的相互干扰最小化，以保持B（0）和B（1）场的质量均匀性。根据功能生物医学信息学研究网络（FBIRN）协议的测量证明了组合系统执行功能性MRI（fMRI）的能力。根据美国电气制造商协会（NEMA）标准评价PET插件的性能。噪声等效计数率（NEC）在7.3 kBq/mL时达到峰值30.7 x 10（3）计数/s。点源灵敏度大于7%。中心视野的空间分辨率小于3 mm。患者数据集清楚地显示出PET和MR图像质量非常好。PET和MRI体模测试和第一个患者数据显示了该设备同时进行多参数成像的潜力。a Euro cent PET和MRI的组合是一种新兴的成像技术。a Euro cent评估的脑部PET/MRI可实现不折不扣的成像性能。a Euro cent PET/MRI旨在提供多参数成像，允许采集形态学和代谢。
Technical performance evaluation of a human brain PET/MRI system.The magnetic field compatible positron emission tomography (PET) insert is based on avalanche photodiode (APD) arrays coupled with lutetium oxyorthosilicate (LSO) crystals and slip-fits into a slightly modified clinical 3-T MRI system. The mutual interference between the two imaging techniques was minimised by the careful design of the hardware to maintain the quality of the B (0) and B (1) field homogeneity.The signal-to-noise ratio (SNR) and the homogeneity of the MR images were minimally influenced by the presence of the PET. Measurements according to the Function Biomedical Informatics Research Network (FBIRN) protocol proved the combined system's ability to perform functional MRI (fMRI). The performance of the PET insert was evaluated according to the National Electrical Manufacturers Association (NEMA) standard. The noise equivalent count rate (NEC) peaked at 30.7 x 10(3) counts/s at 7.3 kBq/mL. The point source sensitivity was greater than 7 %. The spatial resolution in the centre field of view was less than 3 mm. Patient data sets clearly revealed a noticeably good PET and MR image quality.PET and MRI phantom tests and first patient data exhibit the device's potential for simultaneous multiparametric imaging.aEuro cent Combination of PET and MRI is a new emerging imaging technology.aEuro cent Evaluated brain PET/MRI enables uncompromised imaging performance.aEuro cent PET/MRI aims to provide multiparametric imaging allowing acquisition of morphology and metabolism.