The relationship between Triglyceride and glycose (TyG) index and the risk of gynaecologic and breast cancers
The relationship between Triglyceride and glycose (TyG) index and the risk of gynaecologic and breast cancers
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DOI：
10.1016/j.clnesp.2022.08.004
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发表时间：
2022-09-29
影响因子：
3
通讯作者：
Zhou, Huaijun
中科院分区：
文献类型：
--
作者：
Shi, Haimeng;Zhou, Ling;Zhou, Huaijun
背景和目的：甘油三酯葡萄糖（TyG）指数与妇科和乳腺癌的关系尚不清楚。我们假设TyG指数的增加与子宫癌、宫颈癌、卵巢癌和乳腺癌的风险升高有关。方法和结果：对于这项观察性研究，我们收集了国家健康和营养检查调查（NHANSE，1999-2018）的数据。共纳入11466名个体，涉及586名（5.1%）先前诊断为女性生殖组织癌症的个体（即，乳腺、卵巢、宫颈或子宫）。Logistic回归分析TyG指数与妇科和乳腺癌发病率的关系。我们观察到，较高的TyG指数与美国成年人群中妇科和乳腺癌的患病率显著相关。调整多变量后，TyG指数最高四分位数的参与者与最低四分位数的OR = 1.516（95%置信区间（CI）1.121，2.050）（P < 0.05）。此外，TyG指数与女性乳腺癌、宫颈癌、卵巢癌、子宫癌的发病风险相关，OR值分别为2.25，95%可信区间：1.50 ~ 3.37、1.68，0.99 ~ 2.84、3.73，1.01 ~ 13.87、2.42，1.14 ~ 5.16。预测妇科和乳腺癌的最佳截断值为8.70。Kaplan-Meier曲线显示TyG指数>= 8.70的个体癌症死亡率较高（P < 0.05）。在未来的研究中，可能需要更多的证据来评估TyG指数与妇科和乳腺癌发病率的相关性。(c)2022年欧洲临床营养与代谢学会。由爱思唯尔有限公司出版。保留所有权利。
Background and purpose: The relationship between triglyceride glucose (TyG) index and gynaecologic and breast cancers is unclear. We hypothesized that an increase in the TyG index is associated with elevated risk of cancers of the uterine, cervix, ovary and breast. Methods and results: For this observational study, we collected data from the National Health and Nutrition Examination Survey (NHANSE, 1999-2018). A total of 11466 individuals were included, involving 586 (5.1%) individuals with a previous cancer diagnosis in female reproductive tissues (i.e., breast, ovarian, cervical or uterine). Logistic regression was performed to evaluate the association be-tween TyG index and incidence of gynaecologic and breast cancers. We observed that higher TyG index is significantly linked to greater prevalence of gynaecologic and breast cancers in US adult population. After adjustment of multi-variates, participants with the highest quartile of TyG index had an OR = 1.516 (95% confidence interval (CI) 1.121, 2.050) (P < 0.05) versus the lowest. In addition, TyG index was associated with the risk of female cancers of the breast OR per one standard deviation increase 2.25,95% confidence interval:1.50 to 3.37], cervix (1.68,0.99 to 2.84), ovary (3.73,1.01 to 13.87), uterine (2.42,1.14 to 5.16). The optimal cut-off value for predicting gynaecologic and breast cancers is 8.70. Kaplan-Meier curves showed that individuals (TyG index >= 8.70) had higher cancer mortality (P value < 0.05).Conclusions: The Elevated TyG index increases the incidence of cancers in female reproductive tissues. In the future studies, more evidence may be warranted to assess the correlation between TyG index and incidence of gynaecologic and breast cancers.(c) 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.