Disrupted default mode network connectivity in male adolescents with conduct disorder.
Disrupted default mode network connectivity in male adolescents with conduct disorder.
复制标题
行为障碍男性青少年的默认模式网络连接中断
DOI：
10.1007/s11682-015-9465-6
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发表时间：
2016
影响因子：
3.2
通讯作者：
Wang Xiaoping
中科院分区：
文献类型：
--
作者：
Zhou Jiansong;Yao Nailin;Fairchild Graeme;Cao Xia;Zhang Yingdong;Xiang Yu-Tao;Zhang Li;Wang Xiaoping
品行障碍(CD)是一种严重的儿童期和青春期行为障碍。缺省模式网络(DMN)是一种支持自我参照认知过程的大脑网络，通常在任务执行过程中被去激活。这项研究的目的是调查患有单纯CD的男性青少年与典型发育的对照组的DMN连接性。18名患有CD的男性青少年和18名性别、年龄和教育匹配的典型发育(TD)参与者被招募。目前和终身精神障碍的评估使用中文版的学龄儿童情感障碍和精神分裂症-目前和终身版。使用3.0T扫描仪获得静息状态功能磁共振成像(FMRI)数据。独立成分分析(ICA)被用来研究大脑DMN区和相关脑区之间的功能连接。在前额内侧皮质、扣带回后皮质和顶叶外侧皮质观察到DMN活性，并延伸到脑干。与TD对照组相比，CD青少年在双侧扣带后皮质(PCC)、双侧楔前叶和右侧颞上回的功能连接性显著降低。CD与DMN内以及DMN与其他区域之间的功能连接性降低有关。这些初步结果表明，DMN功能连接缺陷可能是CD的一个生物标志物。
Conduct disorder (CD) is a serious behavioral disorder of childhood and adolescence. The default mode network (DMN) is a brain network which supports self-referential cognitive processes and is typically deactivated during task performance. The aim of this study was to investigate DMN connectivity in male adolescents with pure CD compared to typically-developing controls. Eighteen male adolescents with CD and 18 sex-, age- and education-matched typically-developing (TD) participants were recruited. Current and lifetime psychiatric disorders were assessed using the Chinese version of the Schedule for Affective Disorder and Schizophrenia for School-Age Children-Present and Lifetime Version. Resting state functional magnetic resonance imaging (fMRI) data were obtained using a 3.0 T scanner. Independent components analysis (ICA) was used to investigate functional connectivity between the DMN and related brain regions. DMN activity was observed in medial prefrontal, posterior cingulate, and lateral parietal cortices, and extended to the brainstem. Adolescents with CD showed significantly reduced functional connectivity within the bilateral posterior cingulate cortex (PCC), bilateral precuneus and right superior temporal gyrus relative to TD controls. CD is associated with reduced functional connectivity within the DMN and between the DMN and other regions. These preliminary results suggest that deficits in DMN functional connectivity may serve as a biomarker of CD.