Dynamics of intracellular information decoding
Dynamics of intracellular information decoding
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DOI：
10.1088/1478-3975/8/5/055007
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发表时间：
2011-10-01
期刊：
影响因子：
2
通讯作者：
Kamimura, Atsushi
中科院分区：
文献类型：
--
作者：
Kobayashi, Tetsuya J.;Kamimura, Atsushi
即使细胞内反应和环境中的大量内在和外在噪声可能足以削弱或限制它们，各种细胞功能也是稳健的。尤其重要的是细胞决策，其中细胞根据嘈杂的外部信号中传达的信息选择命运或行为。对于鲁棒解码，关键步骤是滤除信息传输过程中不可避免地添加的噪声。自催化磷酸化和自催化去磷酸化（aPadP）循环作为这种信息解码过程的最小和最优实现，最近被提出。在这里，我们详细分析了aPadP循环的动力学性质。我们描述的动态作用的平稳和短期的反应，在确定信息解码的效率和澄清的平稳响应的阈值的最优性和它的信息理论意义。此外，我们研究了aPadP循环对受体失活时间和固有噪声的鲁棒性。最后，我们讨论了信息解码与信息依赖行动、下注对冲和网络模块性之间的关系。
A variety of cellular functions are robust even to substantial intrinsic and extrinsic noise in intracellular reactions and the environment that could be strong enough to impair or limit them. In particular, of substantial importance is cellular decision-making in which a cell chooses a fate or behavior on the basis of information conveyed in noisy external signals. For robust decoding, the crucial step is filtering out the noise inevitably added during information transmission. As a minimal and optimal implementation of such an information decoding process, the autocatalytic phosphorylation and autocatalytic dephosphorylation (aPadP) cycle was recently proposed. Here, we analyze the dynamical properties of the aPadP cycle in detail. We describe the dynamical roles of the stationary and short-term responses in determining the efficiency of information decoding and clarify the optimality of the threshold value of the stationary response and its information-theoretical meaning. Furthermore, we investigate the robustness of the aPadP cycle against the receptor inactivation time and intrinsic noise. Finally, we discuss the relationship among information decoding with information-dependent actions, bet-hedging and network modularity.