Demographic history has influenced nucleotide diversity in European Pinus sylvestris populations
Demographic history has influenced nucleotide diversity in European Pinus sylvestris populations
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DOI：
10.1534/genetics.107.077099
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发表时间：
2007-11-01
期刊：
影响因子：
3.3
通讯作者：
Savolainen, Outi
中科院分区：
文献类型：
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作者：
Pyhajarvi, Tanja;Garcia-Gil, M. Rosario;Savolainen, Outi
为了推断自然选择在形成直立遗传多样性中的作用，有必要评估人口历史对核苷酸多样性的全基因组影响。本研究分析了8个松居群的16个核位点的序列多样性。根据他们目前的位置和该地区的地理历史，人口被分为四个地理组：北欧、中欧、西班牙和土耳其。沉默核苷酸多样性水平各组间无差异，各组间差异均为0.005/bp。有一些证据表明，联系不平衡在北欧比在中欧延伸得更远：种群重组率参数p的估价值分别为0.0064和0.0294。中欧和北欧人口中核苷酸多样性的汇总统计数据与一个古老的瓶颈相容，而不是标准的中性模型。
To infer the role of natural selection in shaping standing genetic diversity, it is necessary to assess the genomewide impact of demographic history on nucleotide diversity. In this study we analyzed sequence diversity of 16 nuclear loci in eight Pinus sylvestris populations. Populations were divided into four geographical groups on the basis of their current location and the geographical history of the region: northern Europe, central Europe, Spain, and Turkey. There were no among-group differences in the level of silent nucleotide diversity, which was similar to 0.005/bp in all groups. There was some evidence that linkage disequilibrium extended further in northern Europe than in central Europe: the estimates of the population recombination rate parameter, p, were 0.0064 and 0.0294, respectively. The summary statistics of nucleotide diversity in central and northern European populations were compatible with an ancient bottleneck rather than the standard neutral model.