Mortality in a population exposed to dioxin after the Seveso, Italy, accident in 1976: 25 years of follow-up
Mortality in a population exposed to dioxin after the Seveso, Italy, accident in 1976: 25 years of follow-up
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DOI：
10.1093/aje/kwm371
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发表时间：
2008-04-01
影响因子：
5
通讯作者：
Bertazzi, Pier Alberto
中科院分区：
文献类型：
--
作者：
Consonni, Dario;Pesatori, Angela C.;Bertazzi, Pier Alberto
1976年发生的塞维索事故导致意大利米兰北部的一大片人口稠密地区受到2，3，7，8-四氯二苯并对二恶英（TCDD）污染。在这项研究中，作者随访了暴露人群的慢性效应;本文报告了1997-2001年死亡率随访扩展的结果。该研究队列包括278，108名事故发生时居住或在事故发生后10年内移民/出生的受试者，这些受试者居住在三个TCDD土壤水平下降的污染区（A区，非常高; B区，高; R区，低）和包括周围非污染城市的参考区域。生命状态和死因确定完成率为99%。采用Poisson回归计算校正率比和95%置信区间。结果证实了A区（6例死亡;率比= 2.23，95%置信区间：1.00，4.97）和B区（28例死亡;率比= 1.59，95%置信区间：1.09，2.33）淋巴和造血组织肿瘤过度的既往发现。这些地区还显示，事故发生后最初几年内循环系统疾病、慢性阻塞性肺病和女性糖尿病的死亡率有所增加。本研究的结果支持高TCDD暴露后对人类的毒性和致癌风险。
The Seveso accident in 1976 caused a large, populated area north of Milan, Italy, to be contaminated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this study, the authors followed up the exposed population for chronic effects; this paper reports the results of the mortality follow-up extension for 1997-2001. The study cohort includes 278,108 subjects resident at the time of the accident or immigrating/born in the 10 years thereafter in three contaminated zones with decreasing TCDD soil levels (zone A, very high; zone B, high; zone R, low) and in a reference territory comprising surrounding, noncontaminated municipalities. Vital status and cause-of-death ascertainment were 99% complete. Adjusted rate ratios and 95% confidence intervals were calculated by using Poisson regression. Results confirmed previous findings of excesses of lymphatic and hematopoietic tissue neoplasms in zones A (six deaths; rate ratio = 2.23, 95% confidence interval: 1.00, 4.97) and B (28 deaths; rate ratio = 1.59, 95% confidence interval: 1.09, 2.33). These zones also showed increased mortality from circulatory diseases in the first years after the accident, from chronic obstructive pulmonary disease, and from diabetes mellitus among females. A toxic and carcinogenic risk to humans after high TCDD exposure is supported by the results of this study.