Serum selenium is low in newly diagnosed Graves' disease: a population-based study
Serum selenium is low in newly diagnosed Graves' disease: a population-based study
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DOI：
10.1111/cen.12185
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发表时间：
2013-10-01
影响因子：
3.2
通讯作者：
Laurberg, Peter
中科院分区：
文献类型：
--
作者：
Pedersen, Inge Bulow;Knudsen, Nils;Laurberg, Peter
研究背景硒缺乏可能在自身免疫性甲状腺疾病的发生和发展中起重要作用目的比较丹麦人群中新诊断的自身免疫性甲状腺疾病（GD）患者和对照者的血清硒（s-Se）水平。或自身免疫性显性甲状腺功能减退症（AIH）（n=96），甲状腺功能正常且血清甲状腺过氧化物酶抗体（TPO-Ab）水平较高的受试者结果GD患者血清s-Se水平低于正常对照组，而正常对照组血清s-Se水平低于正常对照组，差异有统计学意义（平均值（SD），GD：89.9g/l（18.4）;对照组：98.8g/l（19.7），P < 0.01）。这一点在多变量logistic回归模型中得到证实，该模型调整了年龄、性别、矿物质补充剂、吸烟、地理区域和采样时间（P < 0.01）。在线性模型中，s-Se在AIH患者（平均值（SD）：98.4g/l（24.9））和对照组（P = 0.86）中相似。然而，在多变量模型中，与对照组相比，AIH患者的s-Se略低（P = 0.04）。甲状腺功能正常且TPO抗体高的患者s-Se水平与随机对照组比较差异无统计学意义（线性：P = 0.97;多变量：P = 0.27）。我们的观察支持硒供应不足和明显的自身免疫性甲状腺疾病，特别是GD之间的联系。
Context Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease.Objective To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population.Design and settings S-Se was measured in triplicate by a fluorimetric method.Participants Patients with newly diagnosed Graves' disease (GD) (n=97) or autoimmune overt hypothyroidism (AIH) (n=96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO-Ab) (TPO-Ab > 1500U/ml, n=92) and random controls (n=830).Main outcome measure Differences in s-Se values.Results S-Se was lower in patients with GD than in controls (mean (SD), GD: 89.9g/l (18.4); controls: 98.8g/l (19.7), P < 0.01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0.01). In a linear model, s-Se was similar in patients with AIH (mean (SD): 98.4g/l (24.9)) and in controls (P = 0.86). In the multivariate model however, s-Se was marginally lower in patients with AIH compared to controls (P = 0.04). There was no significant difference in s-Se between euthyroid participants with high TPO-Ab and random controls (linear: P = 0.97; multivariate: P = 0.27).Conclusion Patients with newly diagnosed GD and AIH had significantly lower s-Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD.