Does d-Cycloserine Augmentation of CBT Improve Therapeutic Homework Compliance for Pediatric Obsessive-Compulsive Disorder?
Does d-Cycloserine Augmentation of CBT Improve Therapeutic Homework Compliance for Pediatric Obsessive-Compulsive Disorder?
复制标题
CBT的D-胞丝塞增强是否可以改善儿科强迫症的治疗作业合规性？
DOI：
10.1007/s10826-013-9742-1
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发表时间：
2014-07-01
影响因子：
2.1
通讯作者：
Storch, Eric A.
中科院分区：
文献类型：
--
作者：
Park, Jennifer M.;Small, Brent J.;Geller, Daniel A.;Murphy, Tanya K.;Lewin, Adam B.;Storch, Eric A.
关键词：
Clinical studies in adults and children with obsessive–compulsive disorder (OCD) have shown that d-cycloserine (DCS) can improve treatment response by enhancing fear extinction learning during exposure-based psychotherapy. Some have hypothesized that improved treatment response is a function of increased compliance and engagement in therapeutic homework tasks, a core component of behavioral treatment. The present study examined the relationship between DCS augmented cognitive-behavioral therapy (CBT) and homework compliance in a double-blind, placebo controlled trial with 30 youth with OCD. All children received 10 CBT sessions, the last seven of which included exposure and response prevention paired with DCS or placebo dosed 1 h before the session started. Results suggested that DCS augmented CBT did not predict improved homework compliance over the course of treatment, relative to the placebo augmented CBT group. However, when groups were collapsed, homework compliance was directly associated with treatment outcome. These findings suggest that while DCS may not increase homework compliance over time, more generally, homework compliance is an integral part of pediatric OCD treatment outcome.
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影响因子：
--
作者：
Hofmann, SG;Meuret, AE;Otto, MW
通讯作者：
Otto, MW
DOI：
10.1097/00004583-199511000-00008
发表时间：
1995-11-01
影响因子：
13.3
作者：
DOUGLASS, HM;MOFFITT, TE;SILVA, P
通讯作者：
SILVA, P
影响因子：
10.5
作者：
deAraujo, LA;Ito, LM;Marks, IM
通讯作者：
Marks, IM
DOI：
10.1111/j.0963-7214.2005.00367.x
发表时间：
2005-08-01
影响因子：
7.2
作者：
Davis, M;Myers, KM;Rothbaum, BO
通讯作者：
Rothbaum, BO
影响因子：
4.1
作者：
EDELMAN, RE;CHAMBLESS, DL
通讯作者：
CHAMBLESS, DL