Development of zebrafish (Danio rerio) pectoral fin musculature.
Development of zebrafish (Danio rerio) pectoral fin musculature.
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斑马鱼（Danio rerio）胸鳍肌肉组织的发育。
DOI：
10.1002/jmor.10374
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Hale,ME
中科院分区：
文献类型：
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作者：
Thorsen,DH;Hale,ME
在卵后发育过程中，鱼类的鳍在结构和功能上都发生了显著的变化。在这篇文章中，我们研究了斑马鱼（Danio rerio）从幼虫到成年生活史阶段胸鳍的发育，详细描述了它们的胸肌形态。我们探索肌肉结构的发展作为一种方式来解释鳍在运动中的作用。遗传方法在斑马鱼模型中为检查鳍发育提供了新的工具，我们利用荧光蛋白在特定组织中表达的转基因系来执行详细的三维，体内鳍成像。斑马鱼幼鱼的鳍肌肉组织被组织成两薄层纤维，一个外展肌和一个内收肌，分别位于内骨骼盘的两侧。在幼鱼阶段，肌肉纤维的数量增加，随着纤维朝向发育中的鳍骨架，肌肉片分裂成不同的肌肉分支。在幼年期结束时，胸带和鳍肌肉已经重新定向，呈现出成年组织的样子。我们发现这种形态的变化与鱼鳍功能的转换有关，从幼虫的轴向运动活动到成虫的游泳起始和机动。斑马鱼胸鳍的研究突出了在亚成体发育阶段尚未探索的鳍结构和功能的多样性。j . Morphol。©2005 Wiley‐Liss, Inc。
During posthatching development the fins of fishes undergo striking changes in both structure and function. In this article we examine the development of the pectoral fins from larval through adult life history stages in the zebrafish (Danio rerio), describing in detail their pectoral muscle morphology. We explore the development of muscle structure as a way to interpret the fins' role in locomotion. Genetic approaches in the zebrafish model are providing new tools for examining fin development and we take advantage of transgenic lines in which fluorescent protein is expressed in specific tissues to perform detailed three‐dimensional, in vivo fin imaging. The fin musculature of larval zebrafish is organized into two thin sheets of fibers, an abductor and adductor, one on each side of an endoskeletal disk. Through the juvenile stage the number of muscle fibers increases and muscle sheets cleave into distinct muscle subdivisions as fibers orient to the developing fin skeleton. By the end of the juvenile period the pectoral girdle and fin muscles have reoriented to take on the adult organization. We find that this change in morphology is associated with a switch of fin function from activity during axial locomotion in larvae to use in swim initiation and maneuvering in adults. The examination of pectoral fins of the zebrafish highlights the yet to be explored diversity of fin structure and function in subadult developmental stages. J. Morphol. © 2005 Wiley‐Liss, Inc.