The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.
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转录因子Batf通过调节rorγ - t和rorγ - t靶基因如Il17的表达来控制TH17的分化。在这里，我们报告了Batf控制体内类开关重组（CSR）的机制。在T细胞中，Batf直接控制转录因子Bcl-6和c-Maf的表达，这两种转录因子都是T滤泡辅助细胞（TFH）发育所必需的。在体内恢复Batf - / - T细胞的TFH活性需要Bcl-6和c-Maf的共同表达。在B细胞中，Batf直接控制激活诱导胞苷脱氨酶（AID）和IH-CH种系转录本的表达。因此，Batf在两种细胞类型的多个层次水平上起作用，以全局调节体内开关抗体反应。
The transcription factor Batf controls TH17 differentiation by regulating the expression of both RORγt and RORγt target genes such as Il17. Here, we report the mechanism by which Batf controls in vivo class switch recombination (CSR). In T cells, Batf directly controls expression of the transcription factors Bcl-6 and c-Maf, both of which are needed for development of T follicular helper (TFH) cells. Restoring TFH activity to Batf−/− T cells in vivo requires co-expression of both Bcl-6 and c-Maf. In B cells, Batf directly controls the expression of both activation-induced cytidine deaminase (AID) and of IH-CH germline transcripts. Thus, Batf functions at multiple hierarchical levels across two cell types to globally regulate in vivo switched antibody responses.