Immunohistochemical Profile of Polymorphous Adenocarcinoma of Minor Salivary Gland: A Systematic Review and Meta-Analysis.
Immunohistochemical Profile of Polymorphous Adenocarcinoma of Minor Salivary Gland: A Systematic Review and Meta-Analysis.
复制标题
小唾液腺多形性腺癌的免疫组织化学特征：系统评价和荟萃分析。
DOI：
10.1007/s12105-022-01453-6
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发表时间：
2022
影响因子：
2.1
通讯作者：
Takei,Hidehiro
中科院分区：
文献类型：
--
作者：
Nonaka,Taichiro;Takei,Hidehiro
多形性腺癌（PAC）是一种罕见的小涎腺肿瘤变体。由于其结构的多样性，PAC的组织学诊断可能是困难的，特别是对于小的活检，免疫组化是很大的帮助，在区分它与其组织学模拟。本研究的目的是进行系统的文献综述，以确定可靠的免疫组化标记PAC。我们对MEDLINE、ScienceDirect、SpringerLink和Wiley Online Library数据库进行了电子文献检索，涵盖了1988年至2021年期间发表的文献。入选标准包括病例报告和PAC病例的回顾性研究以及免疫组化标记物的详细信息。在检索和选择过程后，32项研究（409例病例）被纳入本系统性综述。总的来说，> 90%的阳性观察泛细胞角蛋白（CK）（97.3%），CK7（96.8%），CK 7/8型（97.4%），E-钙粘蛋白（90.0%），波形蛋白（92.5%）、S100（97.0%）、p63（91.7%）和SOX 10（100%），而几乎没有观察到CK 20（0.0%）、p40（0.0%）和GFAP（5.0%）的阳性。平均MIB-1标记指数为3.78%。本系统评价的结果表明，CK 7 +/CK 20 −、p63+/p40−、S100+、Vimentin+和GFAP-免疫表型对PAC具有诊断价值。此外，S100、MSA、p40和c-Kit的使用提供了有助于区分PAC与腺样囊性癌的额外信息层，这是具有挑战性的鉴别诊断之一。
Polymorphous adenocarcinoma (PAC) is a rare variant of minor salivary gland tumors. Because of its architectural diversity, histological diagnosis of PAC can be difficult especially for small biopsies, and immunohistochemistry is of great help in differentiating it from its histologic mimics. The aim of this study is to conduct a systematic literature review to identify reliable immunohistochemical markers for PAC. We conducted an electronic literature search of the MEDLINE, ScienceDirect, SpringerLink, and Wiley Online Library databases, covering the literature published in the period between 1988 and 2021. The eligibility criteria included case reports and retrospective studies of PAC cases with details of immunohistochemical markers. Following the search and selection process, 32 studies with 409 cases were included in this systematic review. Overall, > 90% positivity was observed for pan-cytokeratin (CK) (97.3%), CK7 (96.8%), CK7/8 (97.4%), E-cadherin (90.0%), Vimentin (92.5%), S100 (97.0%), p63 (91.7%), and SOX10 (100%), while little to no positivity was observed for CK20 (0.0%), p40 (0.0%), and GFAP (5.0%). The average MIB-1 labeling index was 3.78%. The results of this systematic review indicate that CK7+/CK20−, p63+/p40−, S100+, Vimentin+, and GFAP– immunophenotype have diagnostic value for PAC. In addition, the use of S100, MSA, p40, and c-Kit provide additional layers of information helpful to differentiate PAC from adenoid cystic carcinoma, one of challenging differential diagnoses.