Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network.
Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network.
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DOI：
10.1186/gb-2009-10-9-r91
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发表时间：
2009
期刊：
影响因子：
12.3
通讯作者：
Delisi C
中科院分区：
文献类型：
--
作者：
Linghu B;Snitkin ES;Hu Z;Xia Y;Delisi C
An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies.
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影响因子：
4.3
作者：
Guan Y;Myers CL;Lu R;Lemischka IR;Bult CJ;Troyanskaya OG
通讯作者：
Troyanskaya OG
影响因子：
4.5
作者：
Hancock, Angela M.;Witonsky, David B.;Gordon, Adam S.;Eshel, Gidon;Pritchard, Jonathan K.;Coop, Graham;Di Rienzo, Anna
通讯作者：
Di Rienzo, Anna
影响因子：
12.3
作者：
Fraser HB;Plotkin JB
通讯作者：
Plotkin JB
影响因子：
5.8
作者：
Gaulton, Kyle J.;Mohlke, Karen L.;Vision, Todd J.
通讯作者：
Vision, Todd J.
影响因子：
14.9
作者：
Harris, MA;Clark, J;White, R
通讯作者：
White, R