ADAM-17: the enzyme that does it all.
ADAM-17: the enzyme that does it all.
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DOI：
10.3109/10409231003628015
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发表时间：
2010-04
影响因子：
6.5
通讯作者：
Gooz M
中科院分区：
文献类型：
--
作者：
Gooz M
本文综述了ADAM-17在疾病中的作用。自从作为肿瘤坏死因子转换酶或TACE首次亮相以来，已报道ADAM-17是从增殖到迁移的几乎所有细胞事件的不可或缺的调节剂。ADAM-17在细胞调节中的核心作用源于其多种底物：细胞因子、生长因子及其受体以及粘附分子通过与ADAM-17的切割而被激活或失活。因此，毫不奇怪，ADAM-17与许多人类疾病有关，包括癌症、心脏病、糖尿病、类风湿性关节炎、肾纤维化、阿尔茨海默病，并且是未来治疗的有希望的靶点。ADAM-17在这些疾病的病理生理学中的具体作用非常复杂，并且取决于细胞环境。为了开发ADAM-17的治疗潜力，重要的是要了解其活性是如何调节的，以及如何靶向特定的器官和细胞来激活或激活该酶。
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme or TACE, ADAM-17 has been reported to be an indispensible regulator of almost every cellular event from proliferation to migration. The central role of ADAM-17 in cell regulation is rooted in its diverse array of substrates: cytokines, growth factors, and their receptors as well as adhesion molecules are activated or inactivated by their cleavage with ADAM-17. It is therefore not surprising that ADAM-17 is implicated in numerous human diseases including cancer, heart disease, diabetes, rheumatoid arthritis, kidney fibrosis, Alzheimer’s disease, and is a promising target for future treatments. The specific role of ADAM-17 in the pathophysiology of these diseases is very complex and depends on the cellular context. To exploit the therapeutic potential of ADAM-17, it is important to understand how its activity is regulated and how specific organs and cells can be targeted to inactivate or activate the enzyme.
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