Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.
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DOI：
10.3390/ijms160922830
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发表时间：
2015-09-22
影响因子：
5.6
通讯作者：
Cui H
中科院分区：
文献类型：
--
作者：
Chen L;Cui H
谷氨酰胺代谢在许多肿瘤细胞中被证明是失调的，并且是大多数肿瘤细胞增殖所必需的，这使得谷氨酰胺成为肿瘤治疗的吸引人的靶点。为了被细胞充分利用，谷氨酰胺必须通过特定的转运蛋白转运到细胞中，并通过谷氨酰胺酶转化为谷氨酸。目前有几种针对转氨酶的药物正在开发或临床试验中。此外，谷氨酰胺代谢限制已被证明是有效的抑制肿瘤生长在体内和体外诱导细胞凋亡，生长停滞和/或自噬。本文就谷氨酰胺在肿瘤中的代谢、谷氨酰胺靶向诱导的细胞死亡及其在肿瘤治疗中的作用作一综述。
Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is essential for proliferation of most cancer cells, which makes glutamine an appealing target for cancer therapy. In order to be well used by cells, glutamine must be transported to cells by specific transporters and converted to glutamate by glutaminase. There are currently several drugs that target glutaminase under development or clinical trials. Also, glutamine metabolism restriction has been proved to be effective in inhibiting tumor growth both in vivo and vitro through inducing apoptosis, growth arrest and/or autophagy. Here, we review recent researches about glutamine metabolism in cancer, and cell death induced by targeting glutamine, and their potential roles in cancer therapy.