Chemistry and Biology of Resveratrol-Derived Natural Products.
Chemistry and Biology of Resveratrol-Derived Natural Products.
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DOI：
10.1021/cr500689b
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发表时间：
2015-09-09
期刊：
影响因子：
62.1
通讯作者：
Stephenson CR
中科院分区：
文献类型：
--
作者：
Keylor MH;Matsuura BS;Stephenson CR
自20世纪初以来，由于科学和医学的进步，出生时的平均预期寿命几乎翻了一番。随着医疗记录变得更加可靠，很明显，虽然总体寿命在增加，但地理区域之间存在显著的流行病学差异，日本、法国和瑞士等国家的人的预期寿命比世界其他地区的人更长。造成这些死亡率和发病率差异的因素不仅归因于遗传，还归因于高度变化的生活方式和环境影响。除了现代化和公共卫生政策的差异之外，饮食是跨文化最重要的流行病学因素，被认为是健康和整体福祉的一个极其重要的因素。在20世纪90年代早期之前，人们普遍认为适度饮酒可以显著降低患冠心病的风险。然而，目前尚不清楚这是否适用于所有的酒精饮料，也不清楚饮料中的哪些成分产生了这些有益的特性。1992年，Siemann和Creasy 4报道了白藜芦醇(1)在人体中的显著存在
Since the dawn of the 20th century, the average life expectancy at birth has nearly doubled due to advances in science and medicine. As medical records grew more reliable, it became apparent that, while overall life span was increasing, there were significant epidemiological differences between geographical regions, with people from countries such as Japan, France, and Switzerland enjoying longer life expectancy as compared to other regions of the world. The causative factors for these disparities in both mortality and morbidity have been attributed not only to genetics but also to the contributions of highly variable lifestyle and environmental influences. 1 Barring differences in modernization and public health policy, diet is the most significant epidemiological factor cross-culturally and is thought to be a profoundly important contributor to health and overall well-being.Prior to the early 1990s, there was a general consensus in support of the belief that moderate alcohol consumption significantly lowered the risk of coronary heart disease (CHD). 2 However, it was not clear whether this was true of all alcoholic beverages or which constituents in the drinks were responsible for these beneficial properties. 3 In 1992, Siemann and Creasy 4 reported that resveratrol (1) was present in significant