Role of hepatitis C virus infection in malignant lymphoma in Spain
Role of hepatitis C virus infection in malignant lymphoma in Spain
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DOI：
10.1002/ijc.11727
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发表时间：
2004-08-10
影响因子：
6.4
通讯作者：
Kallinowski, B
中科院分区：
文献类型：
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作者：
De Sanjose, S;Nieters, A;Kallinowski, B
丙型肝炎病毒(丙型肝炎病毒)与恶性淋巴瘤的病因有关。我们估计了与检测到丙型肝炎病毒感染相关的淋巴瘤风险。5例(n=529)是西班牙4个中心1998至2002年间新诊断的淋巴系统恶性肿瘤患者。淋巴瘤的诊断和分类使用世界卫生组织的分类。对照组(n=600)为按5岁年龄组、性别和研究中心配对的住院患者。与严重免疫抑制相关的几种医疗条件排除了对照的资格。患者接受了个人面谈和血液采样。丙型肝炎病毒阳性者被认为是那些对第三代酶联免疫吸附试验或用Amplicor 2.0检测到丙型肝炎病毒核糖核酸有抗体反应的人。对这些病例进行了系统的艾滋病毒抗体检测。我们使用卡方检验和非条件Logistic回归估计优势比(OR)和95%可信区间(95%)。CL)用于与丙型肝炎病毒相关的淋巴瘤。丙型肝炎病毒感染者40例(73%)，对照组23例(3.8%)。16例HIV相关淋巴瘤中6例和8例器官受者相关淋巴瘤中4例为丙型肝炎病毒阳性。这项分析排除了艾滋病毒感染者和器官接受者，导致丙型肝炎病毒在病例中的流行率为5.9%，在对照组中为3.8%。所有淋巴瘤经年龄、性别和中心校正的OR为1.58(95%CI=0.89~2.79)。在所有类型的淋巴瘤中，丙型肝炎病毒与低度恶性B细胞淋巴瘤的风险增加有关(OR=35.98，95%CI=4.70-275.4)。边缘B细胞淋巴瘤、弥漫性大B细胞淋巴瘤和B一氧化氮合酶淋巴瘤与丙型肝炎病毒相关的风险增加了2倍，但相关性没有统计学意义。在西班牙，丙型肝炎病毒感染与免疫功能未严重受损的受试者患广谱淋巴肿瘤的风险增加有关。(C)2004年Wiley-Liss公司
Hepatitis C virus (HCV) has been implicated in the etiology of malignant lymphomas. We estimated the risk of lymphoma associated with detection of HCV infection. Cases (n = 529) were consecutive patients newly diagnosed with a lymphoid malignancy between 1998 and 2002 in 4 centers in Spain. Lymphomas were diagnosed and classified using the WHO Classification. Controls (n = 600) were hospitalized patients matched to the cases by 5-year age group, gender and study center. Several medical conditions associated with severe immunosuppression precluded the eligibility of controls. Patients underwent a personal interview and blood sampling. HCV positive subjects were considered those with antibody response to third generation ELISA or detection of HCV RNA with Amplicor 2.0. Cases were systematically tested for HIV antibodies. We used the chi(2) test and unconditional logistic regression to estimate the odds ratio (OR) and 95% confidence interval (95%. Cl) for lymphoma associated with HCV. HCV infection was detected in 40 cases (73%) and 23 (3.8%) control subjects. Six of 16 patients with HIV-related lymphomas and 4 of 8 organ-recipient-related lymphomas were HCV positive. The analysis, excluding HIV-infected subjects and organ recipients, led to a prevalence of HCV of 5.9% among cases and 3.8% among controls. The age-, gender- and center-adjusted OR for all lymphomas was 1.58 (95% Cl = 0.89-2.79). Among all lymphoma categories, HCV was associated with an increased risk of low grade B-cell lymphomas not otherwise specified (NOS) (OR = 35.98, 95% Cl = 4.70-275.4). A 2-fold excess risk associated to HCV was observed for marginal B-cell lymphomas, diffuse large B-cell lymphoma and lymphoma B NOS but the associations were not statistically significant. HCV infection is associated with an increased risk of a broad spectrum of lymphoid neoplasms among non severely immunocompromised subjects in Spain. (C) 2004 Wiley-Liss, Inc.