The role of complement system in ocular diseases including uveitis and macular degeneration
The role of complement system in ocular diseases including uveitis and macular degeneration
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DOI：
10.1016/j.molimm.2007.06.145
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发表时间：
2007-09-01
影响因子：
3.6
通讯作者：
Bora, Nalini S.
中科院分区：
文献类型：
--
作者：
Jha, Purushottam;Bora, Puran S.;Bora, Nalini S.
在正常眼中，补体系统以低水平持续活化，膜结合和可溶性眼内补体调节蛋白均紧密调节这种自发补体活化。这可以防止病原体，而不会对自身组织造成任何损害和视力丧失。补体系统和补体调节蛋白控制自身免疫性葡萄膜炎的眼内炎症反应，在角膜炎症反应、年龄相关性黄斑变性和糖尿病视网膜病变的发生发展中起重要作用。来自动物模型和患者研究的证据支持补体抑制是治疗各种眼部疾病的相关治疗靶点的概念。目前，一些使用补体抑制剂的临床试验正在进行中，在不久的将来，补体抑制剂有可能被用作眼科临床的治疗药物。(c)2007爱思唯尔有限公司保留所有权利。
In the normal eye, the complement system is continuously activated at low levels and both membrane-bound and soluble intraocular complement regulatory proteins tightly regulate this spontaneous complement activation. This allows protection against pathogens without causing any damage to self-tissue and vision loss. The complement system and complement regulatory proteins control the intraocular inflammation in autoimmune uveitis and play an important role in the development of corneal inflammation, age-related macular degeneration and diabetic retinopathy. The evidence derived from both animal models and patient studies support the concept that complement inhibition is a relevant therapeutic target in the treatment of various ocular diseases. Currently, several clinical trials using complement inhibitors are going on. It is possible that, in the near future, complement inhibitors might be used as therapeutic agents in eye clinics. (c) 2007 Elsevier Ltd. All rights reserved.