Effect of age at the time of vaccination on antibody titers and feedlot performance in beef calves
Effect of age at the time of vaccination on antibody titers and feedlot performance in beef calves
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DOI：
10.2460/javma.233.1.136
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发表时间：
2008-07-01
影响因子：
1.9
通讯作者：
Wright, John C.
中科院分区：
文献类型：
--
作者：
Kirkpatrick, John G.;Step, Douglas L.;Wright, John C.
比较用2种接种策略之一接种的小牛和未接种的对照小牛的抗体应答、饲养场发病率和死亡率、饲养场性能和胴体价值。设计-随机对照临床试验。动物-451头肉牛和小母牛。程序-小牛用改良的活传染性牛鼻气管炎病毒（IBRV）接种，牛病毒性腹泻病毒1型（BVDV 1）和2型（BVDV 2）、副流感病毒3型和牛呼吸道合胞病毒疫苗以及溶血性曼氏杆菌和多杀性巴氏杆菌类毒素，约67和190日龄（组1 ; n = 151）或约167和190日龄（组2; 150）或未接种疫苗（对照组; 150）。血清抗体滴度测定约2，67，167，190和232日龄。发病率和死亡率，饲养场的性能，和胴体值被记录为361牛犊运送到feedlots. Results-countages小牛血清转化为IBRV，BVDV 1，和BVDV 2组1和2比对照组显着较高。接种组小牛的平均治疗成本显著低于对照组小牛，对照组小牛的平均死亡率显著高于第1组小牛。饲养场性能和胴体值没有显着不同groups.Conclusions和临床相关性结果表明，在67和190天的年龄与5抗原修饰的活病毒疫苗接种的肉牛是有效的免疫反应，是在167和190天的年龄接种。
Objective-To compare antibody responses, feedlot morbidity and mortality rates, feedlot performance, and carcass value for calves vaccinated with 1 of 2 vaccination strategies and for unvaccinated control calves.Design-Randomized controlled clinical trial.Animals-451 beef steers and heifers.Procedures-Calves were vaccinated with a modified-live infectious bovine rhinotracheitis virus (IBRV), bovine viral diarrhea virus types 1 (BVDV1) and 2 (BVDV2), parainfluenza type 3 virus, and bovine respiratory syncytial virus vaccine and Mannheimia haemolytica and Pasteurella multocida bacterin-toxoid at approximately 67 and 190 days of age (group 1 ; n = 151) or at approximately 167 and 190 days of age (group 2; 150) or were not vaccinated (control; 150). Serum antibody titers were measured at approximately 2, 67 167 190, and 232 days of age. Morbidity and mortality rates, feedlot performance, and carcass value were recorded for 361 calves shipped to feedlots.Results-Percentages of calves seroconverting to IBRV, BVDV1, and BVDV2 were significantly higher for groups 1 and 2 than for the control group. Mean treatment costs were significantly lower for vaccinated than for control calves, and mean mortality rate was significantly higher for control calves than for group 1 calves. Feedlot performance and carcass value did not vary significantly among groups.Conclusions and Clinical Relevance-Results suggested that vaccination of beef calves with a 5-antigen modified-live virus vaccine at 67 and 190 days of age was as effective in terms of immunologic responses as was vaccination at 167 and 190 days of age.