1-Amino-2′-fucosyllactose inhibits biofilm formation by Streptococcus agalactiae
1-Amino-2′-fucosyllactose inhibits biofilm formation by Streptococcus agalactiae
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DOI：
10.1038/s41429-019-0151-6
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发表时间：
2019-06-01
影响因子：
3.3
通讯作者：
Townsend, Steven D.
中科院分区：
文献类型：
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作者：
Craft, Kelly M.;Townsend, Steven D.
2 '-岩藻糖基乳糖（2'-FL）是人乳中普遍存在的低聚糖。重要的是，这种碳水化合物促进几种双歧杆菌菌株（一类有益的肠道微生物）的生长，并抑制病原体的上皮结合。鉴于这些保护作用，我们选择评估2 '-FL作为抗B族链球菌（GBS）的抗菌剂的潜力。虽然2 '-FL没有任何实质性的抗微生物或抗微生物膜活性，但将2'-FL转化为其还原末端β-胺提供了一种新的抗微生物膜化合物。
2'-Fucosyllactose (2'-FL) is a ubiquitous oligosaccharide in human milk Importantly, this carbohydrate promotes the growth of several strains of Bifidobacteria, a class of beneficial gut commensal, and inhibits epithelial binding of pathogens. In light of these protective effects, we elected to evaluate the potential of 2'-FL to serve as an antibacterial agent against Group B Streptococcus (GBS). While 2'-FL was devoid of any substantial antimicrobial or antibiofilm activity, conversion of 2'-FL to its reducing end beta-amine provided a novel antibiofilm compound.