Molecular and cellular mechanisms of ectodomain shedding.
Molecular and cellular mechanisms of ectodomain shedding.
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DOI：
10.1002/ar.20757
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Park PW
中科院分区：
文献类型：
--
作者：
Hayashida K;Bartlett AH;Chen Y;Park PW
几种膜锚定蛋白的胞外结构域通过称为胞外结构域脱落的受调节的蛋白水解机制作为可溶性蛋白从细胞表面释放。细胞利用胞外域脱落来主动调节表面分子的表达和功能，并调节多种细胞和生理过程。胞外结构域脱落快速将膜相关蛋白转化为可溶性效应物，同时快速降低细胞表面表达水平。对于一些蛋白质，胞外域脱落也是膜内蛋白水解的先决条件，膜内蛋白水解释放受影响分子的胞质结构域和相关信号传导因子以调节转录。胞外结构域脱落是一个受特异性激动剂、拮抗剂和细胞内信号传导途径高度调节的过程。此外，仅约2%的细胞表面蛋白通过胞外域脱落从表面释放，表明细胞选择性地脱落其蛋白质胞外域。本文就胞外域脱落的分子和细胞机制及其在肺发育和疾病中的作用作一综述。
The extracellular domain of several membrane-anchored proteins is released from the cell surface as soluble proteins through a regulated proteolytic mechanism called ectodomain shedding. Cells use ectodomain shedding to actively regulate the expression and function of surface molecules, and modulate a wide variety of cellular and physiological processes. Ectodomain shedding rapidly converts membrane-associated proteins into soluble effectors and, at the same time, rapidly reduces the level of cell surface expression. For some proteins, ectodomain shedding is also a prerequisite for intramembrane proteolysis, which liberates the cytoplasmic domain of the affected molecule and associated signaling factors to regulate transcription. Ectodomain shedding is a process that is highly regulated by specific agonists, antagonists, and intracellular signaling pathways. Moreover, only about 2% of cell surface proteins are released from the surface by ectodomain shedding, indicating that cells selectively shed their protein ectodomains. This review will describe the molecular and cellular mechanisms of ectodomain shedding, and discuss its major functions in lung development and disease.
DOI：
10.1084/jem.172.3.693
发表时间：
1990-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Letellier M;Nakajima T;Pulido-Cejudo G;Hofstetter H;Delespesse G
通讯作者：
Delespesse G