AIBN-Induced Remote Trifluoromethyl-Alkynylation of Thioalkynes.
AIBN-Induced Remote Trifluoromethyl-Alkynylation of Thioalkynes.
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DOI：
10.1021/acs.orglett.0c01147
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发表时间：
2020-05
期刊：
影响因子：
5.2
通讯作者：
Zhimin Xiong;Fang Zhang;Yong-Fei Yu;Ze Tan;Gangguo Zhu
中科院分区：
文献类型：
--
作者：
Zhimin Xiong;Fang Zhang;Yong-Fei Yu;Ze Tan;Gangguo Zhu
描述了一种新型的α,α'-偶氮二异丁腈(AIBN)诱导的硫代炔的远程三氟甲基炔基化反应，其中炔基三氟酮作为三氟甲基和炔烃源。可以通过完全控制区域选择性、立体选择性和位点选择性来构建结构多样的三氟甲基化 (Z)-烯炔，这是快速构建三氟甲基化分子的高度选择性方法。
A novel α,α'-azobis(isobutyronitrile) (AIBN)-induced remote trifluoromethyl-alkynylation of thioalkynes with alkynyl triflones as both the trifluoromethyl and alkyne sources is described. Structurally diverse trifluoromethylated (Z)-enynes can be constructed with full control of regio-, stereo-, and site-selectivity, which serves as a highly selective method for the rapid construction of trifluoromethylated molecules.