Limited accumulation of high-frequency somatic mutations in a 1700-year-old Osmanthus fragrans tree
Limited accumulation of high-frequency somatic mutations in a 1700-year-old Osmanthus fragrans tree
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DOI：
10.1093/treephys/tpac058
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Long Wang
中科院分区：
文献类型：
--
作者：
Yifan Duan;Jiping Yan;Yue Zhu;Cheng Zhang;Xiuhua Tao;Hongli Ji;Min Zhang;Xianrong Wang;Long Wang
Abstract. Lifespan varies greatly between and within species. Mutation accumulation is considered an important factor explaining this life-history trait. However, direct assessment of somatic mutations in long-lived species is still rare. In this study, we sequenced a 1700-year-old sweet olive tree and analysed the high-frequency somatic mutations accumulated in its six primary branches. We found the lowest per-year mutation accumulation rate in this oldest tree among those studied via the whole-genome sequencing approach. Investigation of mutation profiles suggests that this low rate of high-frequency mutation was unlikely to result from strong purifying selection. More intriguingly, on a per-branching scale, the high-frequency mutation accumulation rate was similar among the long-lived individuals such as oak, wild peach and sweet olive investigated here. We therefore suggest the possibility that the accumulation of high-frequency somatic mutations in very long-lived trees might have an upper boundary due to both the possible limited number of stem cell divisions and the early segregation of the stem cell lineage.
