Drinking habits as cofactors of risk for alcohol induced liver damage
Drinking habits as cofactors of risk for alcohol induced liver damage
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DOI：
10.1136/gut.41.6.845
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发表时间：
1997-12-01
期刊：
影响因子：
24.5
通讯作者：
Sassatelli, R
中科院分区：
文献类型：
--
作者：
Bellentani, S;Saccoccio, G;Sassatelli, R
狄俄尼索斯研究是一项关于意大利北方两个社区普通人群慢性肝病患病率的队列研究。它包括6917名受试者，年龄12-65岁（总人口的69%）.目的-这部分研究的目的是在开放人群中检查每日酒精摄入量、消耗的酒精饮料类型和饮酒模式与酒精诱导的肝损伤的存在的关系.患者和方法-6534名受试者，没有病毒相关的慢性肝病，并参加了研究的第一个横断面部分，进行了全面检查。每例受试者接受：（a）病史和体格检查，（B）使用图解饮食问卷评估酒精摄入，和（c）常规血液检查。更多的侵入性诊断程序进行时，indicated.Results-Multivariate分析表明，发展为肝硬化或非硬化性肝损伤（NCLD）的风险阈值是摄入超过30克酒精，每天在男女。使用这个定义，1349人（研究人群的21%）处于风险之中。其中，只有74人（5.5%的风险个体）显示出肝损伤的迹象。“纯”酒精性肝硬化的患病率为0.43%（30/6917），占风险个体的2.2%，男女比例为9：1，而44（3.3%的风险个体）显示出持续的NCLD体征。在50岁以后，发生NCLD和肝硬化的累积风险显著升高（p
Background-The Dionysos Study is a cohort study of the prevalence of chronic liver disease in the general population of two northern Italian communities. It included 6917 subjects, aged 12-65 (69% of the total population).Aims-The aim of this part of the study was to examine the relationship of daily alcohol intake, type of alcoholic beverage consumed, and drinking patterns to the presence of alcohol induced liver damage in an open population.Patients and methods-6534 subjects, free of virus related chronic liver disease and participating in the first cross-sectional part of the study, were fully examined. Each subject underwent: (a) medical history and physical examination, (b) evaluation of alcohol intake using an illustrated dietary questionnaire, and (c) routine blood tests. More invasive diagnostic procedures were performed when indicated.Results-Multivariate analysis showed that the risk threshold for developing either cirrhosis or non-cirrhotic Liver damage (NCLD) was ingestion of more than 30 g alcohol per day in both sexes. Using this definition, 1349 individuals (21% of the population studied) were at risk. Of these, only 74 (5.5% of the individuals at risk) showed signs of liver damage. The prevalence of "pure" alcoholic cirrhosis was 0.43% (30 of 6917), representing 2.2% of the individuals at risk, with a ratio of men to women of 9:1, while 44 (3.3% of the individuals at risk) showed persistent signs of NCLD. After 50 years of age, the cumulative risk of developing both NCLD and cirrhosis was significantly higher (p