Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis
Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis
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DOI：
10.1021/ol0705144
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发表时间：
2007-04-12
期刊：
影响因子：
5.2
通讯作者：
Schrodi, Yann
中科院分区：
文献类型：
--
作者：
Stewart, Ian C.;Ung, Thay;Schrodi, Yann
[图]制备了一系列带有n -杂环碳（NHC）配体的钌基复分解催化剂，其中n -芳基由甲酰基变为单邻位取代苯基（例如，甲苯基）。这些新型催化剂对通过闭合环复分解（RCM）生成四取代烯烃的活性有显著提高，同时在闭合环复分解（RCM）生成二取代烯烃和三取代烯烃的反应中保持高水平的活性。
[GRAPHICS]A series of ruthenium-based metathesis catalysts with N-heterocyclic carbene (NHC) ligands have been prepared in which the N-aryl groups have been changed from mesityl to mono-ortho-substituted phenyl (e.g., tolyl). These new catalysts offer an exceptional increase in activity for the formation of tetrasubstituted olefins via ring-closing metathesis (RCM), while maintaining high levels of activity in ring-closing metathesis (RCM) reactions that generate di- and trisubstituted olefins.