Amygdala response to fearful faces in anxious and depressed children
Amygdala response to fearful faces in anxious and depressed children
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DOI：
10.1001/archpsyc.58.11.1057
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发表时间：
2001-11-01
影响因子：
--
通讯作者：
Casey, BJ
中科院分区：
文献类型：
--
作者：
Thomas, KM;Drevets, WC;Casey, BJ
背景：杏仁核功能的改变与成人焦虑和抑郁障碍的病理生理特征有关。对健康成人和儿童以及患有杏仁核损伤的成人的研究发现，面部表情是杏仁核活动的有用探针。我们的研究检测了健康、焦虑和抑郁儿童的杏仁核对恐惧和中性面部表情的反应。我们假设，儿童焦虑和抑郁可能会表现出非典型的杏仁核反应的情绪stimulation.Methods：12名儿童（8-16岁）与广泛性焦虑或惊恐障碍和12名健康对照儿童进行了非侵入性功能磁共振成像，同时观看照片的恐惧和中性的面部表情。在第二个比较中，5名女孩与重度抑郁症进行了比较，5焦虑和5健康的女孩从以前的samples.Results：儿童焦虑症表现出夸张的杏仁核反应可怕的面孔相比，健康的孩子，而抑郁症的孩子表现出迟钝的杏仁核反应，这些面孔。此外，杏仁核的信号之间的变化幅度的恐惧和中性的面孔与日常焦虑symptoms.Conclusions的严重程度呈正相关：我们的研究结果表明，杏仁核功能的影响，在儿童和青少年时期的焦虑和抑郁。此外，这种干扰似乎是特定于孩子自己的日常焦虑的评级。
Background: Alterations in amygdala function have been implicated in the pathophysiological characteristics of adult anxiety and depressive disorders. Studies with healthy adults and children, as well as with adults who have amygdala lesions, have found facial expressions of emotion to be useful probes of amygdala activity. Our study examined the amygdala response to fearful and neutral facial expressions in healthy, anxious, and depressed children. We hypothesized that children with anxiety and depression may show atypical amygdala responses to emotional stimuli.Methods: Twelve children (8-16 years of age) with generalized anxiety or panic disorder and 12 healthy comparison children underwent noninvasive functional magnetic resonance imaging while viewing photographs of fearful and neutral facial expressions. In a second comparison, 5 girls with major depressive disorder were compared with 5 anxious and 5 healthy girls from the previous sample.Results: Children with anxiety disorders showed an exaggerated amygdala response to fearful faces compared with healthy children, whereas depressed children showed a blunted amygdala response to these faces. In addition, the magnitude of the amygdala's signal change between fearful and neutral faces was positively correlated with the severity of everyday anxiety symptoms.Conclusions: Our results suggest that amygdala function is affected in both anxiety and depression during childhood and adolescence. Moreover, this disruption appears to be specific to the child's own rating of everyday anxiety.