Comorbid substance use and age at onset of schizophrenia
Comorbid substance use and age at onset of schizophrenia
复制标题
DOI：
10.1192/bjp.bp.104.007237
复制
发表时间：
2006-03-01
影响因子：
10.5
通讯作者：
Joyce, EM
中科院分区：
文献类型：
--
作者：
Barnes, TRE;Mutsatsa, SH;Joyce, EM
背景物质使用可能是精神分裂症发病的一个危险因素，目的是研究物质使用和发病年龄之间的关系，在英国，内城样本的人与最近发病的Schizophrenia.Method研究样本包括152人招募到西伦敦首发精神分裂症研究自我报告的数据，药物和酒精的使用，以及信息的年龄在精神病发作，被收集起来。精神状态，认知（智商，记忆力和执行功能）和社会功能也assessed.Results在总数中，60%的参与者是吸烟者，27%的人报告的问题与酒精使用的历史，35%的报告目前的物质使用（不包括酒精），和68%的报告终身物质使用（大麻和精神兴奋剂是最常用的）。大麻的使用和性别有独立的影响，在精神病发作的年龄，调整酒精滥用和使用其他drugs.Conclusions自我报告的大麻使用和精神病的早期发作之间的强关联提供了进一步的证据，精神分裂症可能是由大麻使用和/或早期发作的症状是大麻使用的危险因素。
Background Substance use may be a risk factor for the onset of schizophrenia.Aims To examine the association between substance use and age at onset in a UK, inner-city sample of people with recent-onset schizophrenia.Method The study sample consisted of 152 people recruited to the West London First-Episode Schizophrenia Study Self-reported data on drug and alcohol use, as well as information on age at onset of psychosis, were collected. Mental state, cognition (IQ, memory and executive function) and social function were also assessed.Results In total, 60% of the participants were smokers, 27% reported a history of problems with alcohol use, 35% reported current substance use (not including alcohol), and 68% reported lifetime substance use (cannabis and psychostimulants were most commonly used). Cannabis use and gender had independent effects on age at onset of psychosis, after adjusting for alcohol misuse and use of other drugs.Conclusions The strong association between self-reported cannabis use and earlier onset of psychosis provides further evidence that schizophrenia may be precipitated by cannabis use and/or that the early onset of symptoms is a risk factor for cannabis use.