2 TYPES OF VAGAL PREGANGLIONIC MOTONEURONS PROJECTING TO HEART AND LUNGS
2 TYPES OF VAGAL PREGANGLIONIC MOTONEURONS PROJECTING TO HEART AND LUNGS
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DOI：
10.1113/jphysiol.1978.sp012468
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发表时间：
1978-01-01
影响因子：
5.5
通讯作者：
SPYER, KM
中科院分区：
文献类型：
--
作者：
MCALLEN, RM;SPYER, KM
研究人员对猫疑核中的细胞（84）进行了研究，这些细胞的轴突投射到右侧迷走神经的心脏（74）和肺（10）分支。它们的轴突传导速度均在B纤维范围内（2.8-15.5 m/s）。肺分支投射神经元通常是自发活动的（9/10）并与吸气同步激发。他们的活动没有表现出脉冲调制。心脏分支投射神经元 (10) 的特性与肺分支投射神经元的特性没有区别。投射到任一分支的吸气放电细胞被认为具有支气管收缩功能。其余 64 个投射到心脏分支的细胞具有心脏抑制神经元的预期特性。大多数（54）是沉默的，直到被兴奋性氨基酸的离子电渗疗法激活。所有受试者在活动时均显示呼气放电，在 27 名测试者中，23 名显示其放电的心脏调节。当主动脉压力感受器去神经支配时，心律总是通过颈动脉闭塞可逆地消除。离子电渗激活呼气放电（假定心脏抑制）细胞减慢心脏速度（测试了 15/18 个神经元）。兴奋的吸气放电细胞从未产生过这种效果（测试了 11 个）。两种类型的神经元都在疑核中被发现，但推测的心脏抑制细胞通常比推测的支气管收缩神经元更位于尾侧和腹侧。
Cells (84) in the cat''s nucleus ambiguus whose axons projected to the cardiac (74) and pulmonary (10) branches of the right vagus were studied. Their axonal conduction velocities were all in the range of B fibers (2.8-15.5 m/s). Pulmonary branch-projecting neurons were usually spontaneously active (9/10) and fired in phase with inspiration. Their activity showed no pulse modulation. Cardiac branch-projecting neurons (10) had properties indistinguishable from those of pulmonary branch-projecting neurons. Inspiratory-firing cells projecting to either branch are believed to be bronchoconstrictor in function. The remaining 64 cells that projected to the cardiac branch had properties expected of cardioinhibitory neurons. Most (54) were silent until activated by ionophoresis of excitant amino acids. All showed an expiratory discharge when active and of 27 tested, 23 showed a cardiac modulation of their discharge. When the aortic baroreceptors were denervated, the cardiac rhythm was always abolished reversibly by carotid occlusion. Ionophoretic activation of expiratory-firing (presumed cardioinhibitory) cells slowed the heart (15/18 neurons tested). Excited inspiratory-firing cells never had this effect (11 tested). Both types of neurons were found in the nucleus ambiguus, but presumed cardioinhibitory cells were often found more caudal and ventral than presumed bronchoconstrictor neurons.