Therapeutic strategies against tardive dyskinesia. Two decades of experience.
Therapeutic strategies against tardive dyskinesia. Two decades of experience.
复制标题
针对迟发性运动障碍的治疗策略。
DOI：
10.1001/archpsyc.1982.04290070037008
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发表时间：
1982
影响因子：
--
通讯作者：
R. Wyatt
中科院分区：
文献类型：
--
作者：
D. Jeste;R. Wyatt
We reviewed 285 treatment studies involving more than 3,000 patients with neuroleptic-induced tardive dyskinesia (TD). Neuroleptic withdrawal is found to reverse dyskinesia in about 37% of patients. There is no satisfactory treatment for persistent TD. Although neuroleptics are significantly superior to most other methods of treatment in suppressing signs of dyskinesia, the safety of their long-term use in dyskinetic patients remains to be demonstrated. Putative gamma-aminobutyric acid (GABA)-ergic drugs and noradrenergic blockers deserve careful study. A strategy for determining biochemical and pharmacologic subtypes of TD appears promising. The value of the available cholinergic agents in the treatment of TD is uncertain. Caution is warranted in interpreting "positive" results with a number of other drugs, which might act as placebos or as nonspecific sedatives. Anticholinergic drugs are generally not recommended for treating dyskinetic patients. Current theories of the pathophysiology of TD may need revision. Drug-free periods do not seem to prevent TD. Antipsychotic drugs without neuroleptic side effects should be developed.
迟发性运动障碍的患病率、严重程度和恢复情况随年龄的变化。
影响因子：
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作者：
Smith,JM;Baldessarini,RJ
通讯作者：
Baldessarini,RJ
可乐定可改善吉尔·德拉抽动秽语综合征。
影响因子：
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作者：
Cohen,DJ;Detlor,J;Young,JG;Shaywitz,BA
通讯作者：
Shaywitz,BA