Social and sexual motivation in the mouse
Social and sexual motivation in the mouse
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DOI：
10.1037/0735-7044.119.6.1628
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发表时间：
2005-12-01
影响因子：
1.9
通讯作者：
Pfaff, DW
中科院分区：
文献类型：
--
作者：
Matthews, TJ;Abdelbaky, P;Pfaff, DW
性接触对习得的操作性反应有奖励价值吗？训练具有或不具有雌二醇替代的卵巢切除的雌性小鼠对雄性或雌性目标进行杆接触操作性反应。雌激素替代治疗的女性的应答率与未使用雌激素替代治疗的女性或接受雌激素替代治疗的女性的应答率没有差异。反射性接受性行为仍然对雌二醇替代反应。实验2表明，社会孤立的女性会更快地响应访问一个女性目标时，组住房。最后，催产素阻断剂阿托西班减少了操作性和反射性的社会行为。这些结果汇聚的结论，社会和性接触的操作性奖励价值主要是社会。
Does a sexual encounter have reward value for a learned operant response? Ovariectomized female mice with or without estradiol replacement were trained to perform a bar-contact operant response for either male or female targets. Response rates of females with estradiol replacement did not differ from those of females without estradiol replacement or females responding for access to females. Reflexive receptive sexual behavior remained responsive to estradiol replacement. Experiment 2 demonstrated that socially isolated females would respond faster for access to a female target than when group housed. Finally, the oxytocin blocker, atosiban, reduced both operant and reflexive social behavior. These results converge on the conclusion that the operant reward value of social and sexual contact is primarily social.