Heterochromatin replication goes hand in hand with telomere protection
Heterochromatin replication goes hand in hand with telomere protection
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DOI：
10.1038/s41594-020-0400-1
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发表时间：
2020-03-30
影响因子：
16.8
通讯作者：
Gilson, Eric
中科院分区：
文献类型：
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作者：
Mendez-Bermudez, Aaron;Giraud-Panis, Marie-Josephe;Gilson, Eric
端粒的产生源于稳定天然染色体末端的需要，从而产生具有特定保护功能的末端染色质结构。它们的组成蛋白还在异染色质内执行一般功能，介导晚期复制并促进分叉进展。对控制异染色质复制机制的新见解表明，端粒和异染色质在发育和衰老过程中协同作用。他们还提出了真核发生过程中出现的这两个染色体区域的共同进化起源。
Telomeres arose from the need to stabilize natural chromosome ends, resulting in terminal chromatin structures with specific protective functions. Their constituent proteins also execute general functions within heterochromatin, mediating late replication and facilitating fork progression. Emerging insights into the mechanisms governing heterochromatin replication suggest telomeres and heterochromatin act in concert during development and aging. They also suggest a common evolutionary origin for these two chromosome regions that arose during eukaryogenesis.