PATERNAL AGE AND MENTAL FUNCTIONS OF PROGENY IN MAN
PATERNAL AGE AND MENTAL FUNCTIONS OF PROGENY IN MAN
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DOI：
10.1093/oxfordjournals.humrep.a136988
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发表时间：
1989-10-01
影响因子：
6.1
通讯作者：
SCHWARTZ, D
中科院分区：
文献类型：
--
作者：
AUROUX, MR;MAYAUX, MJ;SCHWARTZ, D
母亲年龄对后代质量的影响是众所周知的。除了父亲年龄增加在许多常染色体显性遗传病的发病中所起的作用外，由父亲的S年龄引起的这些因素并不明显。但一个实验模型表明，在大鼠中，父亲年龄的增加，如果没有任何其他异常，可能会导致后代学习能力下降。这里提出的流行病学调查的目的是验证这种影响是否也可能发生在人类身上。这项研究涉及18岁男性受试者根据他们出生时父亲S的年龄，在心理测试中获得的分数的分布。这一分布表明，父亲年龄的增加不仅伴随着与在动物身上观察到的类似的影响，而且非常年轻的父亲年龄也与这些影响有关。因此，这些分数的曲线呈倒U形，在父亲大约30岁时获得最大分数。母亲的年龄似乎并没有在这一事件中发挥作用。这些结果提出了确定可能对受孕质量产生影响的遗传和/或心理社会因素的问题。
The effects of maternal age on the quality of offspring are well known. Those due to the father''s age are less obvious, apart from the role of increasing paternal age in the onset of many dominant autosomal disorders. But an experimental model has demonstrated that, in rats, increasing paternal age, without any other anomalies, might produce a decreased learning capacity in progeny. The object of the epidemiological investigation presented here was to verify whether this effect might also occur in man. The study involved the distribution of scores obtained in psychometric tests by 18-year-old male subjects, according to their father''s age at the time of their birth. This distribution indicated not only that increasing paternal age is accompanied by effects similar to those observed in animals, but also that very young paternal age was also related to these effects. Thus, the curve of such scores produced an inverted U-shape, with maximum scores obtained when the father was about thirty years of age. Maternal age did not appear to play a part in this event. These results pose the problem of identifying genetic and/or psychosocial factors which might have an impact on the quality of the conceptus.