Defining the Cardiac Fibroblast.
Defining the Cardiac Fibroblast.
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DOI：
10.1253/circj.cj-16-1003
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发表时间：
2016-10-25
期刊：
影响因子：
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通讯作者：
Tallquist MD
中科院分区：
文献类型：
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作者：
Ivey MJ;Tallquist MD
心脏纤维化仍然是一个重要的健康问题，但成纤维细胞生物学的研究一直受到阻碍，缺乏有效的手段来识别和跟踪成纤维细胞。成纤维细胞特异性谱系标签和报告基因的最新进展使人们能够更好地了解这些细胞。在损伤后，多种细胞类型被认为是细胞外基质产生细胞的来源，但新兴的研究表明，常驻心脏成纤维细胞对重塑过程有很大贡献。在这篇综述中，我们讨论了最近的研究结果，心脏成纤维细胞的起源和身份。我们对心脏成纤维细胞生物学和纤维化的理解仍在发展中，并将在未来几年内深入扩展，最近关于成纤维细胞基因表达和行为的许多发现为解释这些细胞在损伤前后的目的和用途奠定了基础。
Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent advances in fibroblast-specific lineage tags and reporters have permitted a better understanding of these cells. After injury multiple cell types have been implicated as the source for extracellular matrix producing cells, but emerging studies suggest that resident cardiac fibroblasts contribute substantially to the remodeling process. In this review, we discuss recent findings regarding cardiac fibroblast origin and identity. Our understanding of cardiac fibroblast biology and fibrosis is still developing and will expand profoundly in the next few years, with many of the recent findings regarding fibroblast gene expression and behavior laying down the groundwork for interpreting the purpose and utility of these cells before and after injury.