MENOPAUSE IS ASSOCIATED WITH A SIGNIFICANT INCREASE IN BLOOD MONOCYTE NUMBER AND A RELATIVE DECREASE IN THE EXPRESSION OF ESTROGEN-RECEPTORS IN HUMAN PERIPHERAL MONOCYTES
MENOPAUSE IS ASSOCIATED WITH A SIGNIFICANT INCREASE IN BLOOD MONOCYTE NUMBER AND A RELATIVE DECREASE IN THE EXPRESSION OF ESTROGEN-RECEPTORS IN HUMAN PERIPHERAL MONOCYTES
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DOI：
10.1111/j.1600-0897.1995.tb00965.x
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发表时间：
1995-12-01
影响因子：
3.6
通讯作者：
KOHEN, F
中科院分区：
文献类型：
--
作者：
BENHUR, H;MOR, G;KOHEN, F
目的：探讨雌激素受体(ER)在人单核细胞中差异表达的临床意义。方法：对年轻女性、绝经后女性和接受雌激素替代治疗的女性外周血标本进行双色流式细胞术分析。结果：绝经后ER阳性单核细胞百分率明显下降，血中单核细胞数明显增加，经雌激素替代治疗后，单核细胞数下降至青年组水平。结论：雌激素对单核细胞数有调节作用，其作用可能是通过单核细胞内ER介导的。
PROBLEM: The clinical significance of the differential expression of estrogen receptor (ER) in human monocytes was evaluated.METHOD: Two color flow cytometry analysis was used on peripheral blood samples of young and postmenopausal females and postmenopausal females treated with estrogen replacement therapy. In addition, the monocyte and lymphocyte counts and the blood estrogen levels of each patient were determined.RESULTS: During menopause there is a significant decrease in the percentage of ER positive monocytes, and an increase in blood monocyte number, which declines following estrogen replacement therapy to values of the young.CONCLUSIONS: These findings suggest that estrogen modulates the monocyte numbers and its effects may be mediated through the ER in the monocytes.