Borna disease virus. A possible etiologic factor in human affective disorders?
Borna disease virus. A possible etiologic factor in human affective disorders?
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博尔纳病病毒。
DOI：
10.1001/archpsyc.1985.01790340077011
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发表时间：
1985
影响因子：
--
通讯作者：
Hilary Koprowski
中科院分区：
文献类型：
--
作者：
Jay D. Amsterdam;Andrew Winokur;William L. Dyson;Sibylle Herzog;Francisco Gonzalez;R. Rott;Hilary Koprowski
博尔纳病病毒是一种独特的嗜神经剂，似乎对大脑边缘系统区域有偏好。在某些动物物种中，它可以产生以攻击和被动阶段为特征的行为综合征。这种综合症与某些人类情感障碍有相似之处。在这项初步研究中，我们通过检测265名单相或双相抑郁症患者和105名正常健康志愿者的病毒特异性抗体，研究了博尔纳病病毒在人类情绪障碍病因学中的可能参与。12例患者（4.5%）和无健康对照显示这种抗体在他们的血清样品。有必要复制和扩展这些有趣的初步结果，以确定博尔纳病病毒是否可能参与人类情感障碍的发病机制。
Borna disease virus is a unique neurotropic agent that appears to have a predilection for the limbic area of the brain. In some animal species, it can produce a behavioral syndrome characterized by aggressive and passive phases. This syndrome has suggested an analogy to certain human affective disorders. In this preliminary study, we examined the possible involvement of Borna disease virus in the etiology of human mood disorders by assaying for virus-specific antibodies in 265 patients with unipolar or bipolar depression and 105 normal, healthy volunteers. Twelve patients (4.5%) and none of the healthy controls demonstrated this antibody in their serum samples. It will be necessary to replicate and extend these intriguing preliminary results to determine if Borna disease virus is possibly involved in the pathogenesis of affective disorders in humans.