Brief encounter
Brief encounter
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DOI：
10.1083/jcb.1751iti5
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发表时间：
2006-10-09
期刊：
影响因子：
--
通讯作者：
Leslie M
中科院分区：
文献类型：
--
作者：
Leslie M
地铁乘客可以把肘部拉进去，但上皮层的细胞无法避免接触其他细胞。相反，它们倾向于呈现六边形形状，其中膜被拉紧。先前的研究表明，蛋白质钙粘蛋白和肌动蛋白有助于在细胞相遇的边界形成粘附连接。神秘的是，是什么控制着这些交叉点之间的膜张力？为了找到答案，Otani等人研究了很少研究的Tuba蛋白，它属于一组间接调节肌动蛋白的因子。研究人员发现，Tuba在细胞边缘堆积。用RNAi降低其水平会导致细胞膜下垂，这表明该分子
Subway passengers can pull in their elbows, but cells in an epithelial layer cannot avoid touching other cells. Instead, they tend to assume a hexagonal shape in which the membrane is stretched tight. Previous studies suggest that the proteins cadherin and actin help structure the adherens junctions that form at the borders where cells meet. The mystery is, what controls the membrane’s tension between these intersections?To find out, Otani et al. investigated the little-studied protein Tuba, which belongs to a group of factors that indirectly regulate actin. The researchers found that Tuba built up at cell edges. Cutting its levels with RNAi caused the cell membrane to sag, indicating that the molecule