Reporting bias in imaging: higher accuracy is linked to faster publication
Reporting bias in imaging: higher accuracy is linked to faster publication
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DOI：
10.1007/s00330-018-5354-x
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发表时间：
2018-09-01
影响因子：
5.9
通讯作者：
McInnes, M. D. F.
中科院分区：
文献类型：
--
作者：
Sharifabadi, A. Dehmoobad;Korevaar, D. A.;McInnes, M. D. F.
本研究的目的是评估在影像学诊断准确性研究中，报告的准确性估计值较高是否与发表时间较短相关。我们纳入了2015年发表的系统评价荟萃分析中的主要影像学诊断准确性研究。对于每项主要研究，我们提取了准确性估计值、参与者招募期和出版日期。我们的主要结果是Youden指数（敏感性+特异性-1，诊断准确性的单一指标）和发表时间之间的关系。我们纳入了55篇系统性综述和781篇主要研究。238项（30%）研究的研究完成日期缺失。其余543项研究从完成到发表的中位时间为20个月（IQR 14-29）。约登指数与从完成到发表的时间呈负相关（rho =-0.11，p = 0.009）。在对7个研究特征进行调整后，这种关联在多变量考克斯回归分析中仍然显著：约登指数的logit转换估计值每增加1个单位，发表的风险比为1.09（95%CI 1.03-1.16，p = 0.004）。当用中位数分割Youden的指数时，从完成到出版的时间是20个月（IQR 13-33）对于Youden指数低于中位数的研究，约登指数高于中位数的研究为19个月（14-27）（p = 0.104）准确性评估较高的影像诊断准确性研究与发表时间较短相关性较弱。估计值与较短的发表时间相关性较弱。a欧元美分在多元考克斯回归分析中，发表时间的滞后仍然显着。a欧元美分未发现准确性与从提交到发表的时间之间存在相关性。
The objective of this study was to evaluate whether higher reported accuracy estimates are associated with shorter time to publication among imaging diagnostic accuracy studies.We included primary imaging diagnostic accuracy studies, included in meta-analyses from systematic reviews published in 2015. For each primary study, we extracted accuracy estimates, participant recruitment periods and publication dates. Our primary outcome was the association between Youden's index (sensitivity + specificity - 1, a single measure of diagnostic accuracy) and time to publication.We included 55 systematic reviews and 781 primary studies. Study completion dates were missing for 238 (30%) studies. The median time from completion to publication in the remaining 543 studies was 20 months (IQR 14-29). Youden's index was negatively correlated with time from completion to publication (rho = -0.11, p = 0.009). This association remained significant in multivariable Cox regression analyses after adjusting for seven study characteristics: hazard ratio of publication was 1.09 (95% CI 1.03-1.16, p = 0.004) per unit increase for logit-transformed estimates of Youden's index. When dichotomizing Youden's index by a median split, time from completion to publication was 20 months (IQR 13-33) for studies with a Youden's index below the median, and 19 months (14-27) for studies with a Youden's index above the median (p = 0.104).Imaging diagnostic accuracy studies with higher accuracy estimates were weakly associated with a shorter time to publication.aEuro cent Higher accuracy estimates are weakly associated with shorter time to publication.aEuro cent Lag in time to publication remained significant in multivariate Cox regression analyses.aEuro cent No correlation between accuracy and time from submission to publication was identified.