Genetics of brain fiber architecture and intellectual performance.
Genetics of brain fiber architecture and intellectual performance.
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DOI：
10.1523/jneurosci.4184-08.2009
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发表时间：
2009-02-18
期刊：
影响因子：
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通讯作者：
Thompson PM
中科院分区：
文献类型：
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作者：
Chiang MC;Barysheva M;Shattuck DW;Lee AD;Madsen SK;Avedissian C;Klunder AD;Toga AW;McMahon KL;de Zubicaray GI;Wright MJ;Srivastava A;Balov N;Thompson PM
本文首次分析了影响脑纤维结构的遗传和环境因素及其与认知功能的遗传联系。我们在高磁场（4特斯拉）下使用扩散张量成像（DTI）对92对同卵和异卵双胞胎的白质完整性进行了体向评估。使用分数各向异性（FA）量化的白质完整性用于拟合大脑每个点的结构方程模型（SEM），生成遗传力的3D图。我们可视化了白质完整性与全面、语言和表现智商（FIQ、VIQ和PIQ）之间相关性的解剖剖面。白质完整性（FA）在双侧额叶（a2 = 0.55, P = 0.04，左；a2 = 0.74, P = 0.006，右）、双侧顶叶(a2 = 0.85, P < 0.001，左；a2 = 0.84, P < 0.001，右)和左枕叶（a2 = 0.76, P = 0.003），并与扣带、视神经辐射、额枕上束、内囊、胼胝体峡和辐射冠的FIQ和PIQ相关（FIQ的P = 0.04， PIQ的P = 0.01，经多次比较校正）。在跨性状定位方法中，共同的遗传因素介导了智商和白质完整性之间的相关性，表明两者具有共同的生理机制和共同的遗传决定。这些大脑遗传图谱揭示了白质完整性的遗传方面，并将加速发现影响纤维连接和认知的单核苷酸多态性。
The paper is the first to analyze genetic and environmental factors that affect brain fiber architecture and its genetic linkage with cognitive function. We assessed white matter integrity voxelwise using diffusion tensor imaging (DTI) at high magnetic field (4 Tesla), in 92 identical and fraternal twins. White matter integrity, quantified using fractional anisotropy (FA), was used to fit structural equation models (SEM) at each point in the brain, generating 3D maps of heritability. We visualized the anatomical profile of correlations between white matter integrity and full-scale, verbal, and performance intelligence quotients (FIQ, VIQ, and PIQ). White matter integrity (FA) was under strong genetic control and was highly heritable in bilateral frontal (a2 = 0.55, P = 0.04, left; a2 = 0.74, P = 0.006, right), bilateral parietal (a2 = 0.85, P < 0.001, left; a2 = 0.84, P < 0.001, right) and left occipital (a2 = 0.76, P = 0.003) lobes, and was correlated with FIQ and PIQ in the cingulum, optic radiations, superior fronto-occipital fasciculus, internal capsule, callosal isthmus, and the corona radiata (P = 0.04 for FIQ and P = 0.01 for PIQ, corrected for multiple comparisons). In a cross-trait mapping approach, common genetic factors mediated the correlation between IQ and white matter integrity, suggesting a common physiological mechanism for both, and common genetic determination. These genetic brain maps reveal heritable aspects of white matter integrity and should expedite the discovery of single-nucleotide polymorphisms affecting fiber connectivity and cognition.