The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
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DOI：
10.1093/nar/25.24.4876
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发表时间：
1997-12-15
影响因子：
14.9
通讯作者：
Higgins, DG
中科院分区：
文献类型：
--
作者：
Thompson, JD;Gibson, TJ;Higgins, DG
CLUSTAL X是广泛使用的渐进多序列比对程序CLUSTAL W的新窗口界面，新系统易于使用，提供了一个执行多个序列和轮廓比对并分析结果的集成系统，CLUSTAL X在屏幕上的窗口中显示序列比对，通用的序列着色方案允许用户突出显示比对中的保守特征，下拉菜单提供传统多序列和轮廓比对所需的所有选项，新功能包括：能够剪切和粘贴序列以更改比对顺序，选择要重新比对的序列子集，对要重新比对并插入原始比对的比对的子范围进行比对和选择，可以执行比对质量分析，并且可以突出显示得分较低的片段或异常残基，所选残基范围的质量分析和重新比对为用户提供了改进和改进困难比对并捕获输入序列中的错误的强大工具，CLUSTAL X已经在SUN Solaris、Silicon Graphics上的IRIX5.3、DECStation上的Digital Unix、PC上的Microsoft Windows(32位)、x86 PC上的Linux ELF和Macintosh PowerMac上编译。
CLUSTAL X is a new windows interface for the widely-used progressive multiple sequence alignment program CLUSTAL W, The new system is easy to use, providing an integrated system for performing multiple sequence and profile alignments and analysing the results, CLUSTAL X displays the sequence alignment in a window on the screen, A versatile sequence colouring scheme allows the user to highlight conserved features in the alignment, Pull-down menus provide all the options required for traditional multiple sequence and profile alignment, New features include: the ability to cut-and-paste sequences to change the order of the alignment, selection of a subset of the sequences to be realigned, and selection of a sub-range of the alignment to be realigned and inserted back into the original alignment, Alignment quality analysis can be performed and low-scoring segments or exceptional residues can be highlighted, Quality analysis and realignment of selected residue ranges provide the user with a powerful tool to improve and refine difficult alignments and to trap errors in input sequences, CLUSTAL X has been compiled on SUN Solaris, IRIX5.3 on Silicon Graphics, Digital UNIX on DECstations, Microsoft Windows (32 bit) for PCs, Linux ELF for x86 PCs, and Macintosh PowerMac.