Physical activity, sedentary time, and risk of colorectal cancer: the Singapore Chinese Health Study
Physical activity, sedentary time, and risk of colorectal cancer: the Singapore Chinese Health Study
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DOI：
10.1097/cej.0000000000000369
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发表时间：
2017-11-01
影响因子：
2.4
通讯作者：
Butler, Lesley M.
中科院分区：
文献类型：
--
作者：
Eaglehouse, Yvonne L.;Koh, Woon-Puay;Butler, Lesley M.
过去 40 年来，新加坡的结直肠癌发病率显着上升。西欧和美国前瞻性研究的证据表明，体力活动少和久坐时间长与结直肠癌风险增加有关。本研究的目的是评估亚洲人群中的这些关系。新加坡华人健康研究在 1993 年至 1998 年间招募了 63 257 名成年人。在招募时，参与者报告了过去一年的身体活动和坐着的时间。截至 2014 年 12 月 31 日，确定了结直肠癌发病率 (n= 1994)。使用 Cox 比例风险模型计算风险比 (HR) 和针对潜在混杂因素进行调整的 95% 置信区间 (CI)。该群体中分别有 13.7% 和 22.1% 的人报告过剧烈或中等强度的体力活动。剧烈剧烈的体力活动与显着降低结直肠癌风险具有统计学意义（HR= 0.85；95% CI：0.74-0.99，每周 >= 0.5 小时与无），但中等强度的体力活动则不然。在按看电视时间进行分层的分析中，对于那些自称每天至少坐着看电视 3 小时的人，观察到中等体力活动与结直肠癌风险之间呈负相关（HR= 0.86；95% CI：0.72-1.01，每周 >= 0.5 小时与无）（P 交互作用=0.042）。参加慢跑、游泳或重体力劳动等剧烈体力活动与新加坡华人结直肠癌风险降低有关。需要对亚洲人群的体力活动和久坐行为（单独和组合）以及结直肠癌风险进行进一步研究。版权所有 (C) 2017 Wolters Kluwer Health, Inc. 保留所有权利。
Singapore has experienced a marked increase in colorectal cancer incidence over the past 40 years. Evidence from prospective studies in Western Europe and the USA suggests that low physical activity and high amounts of sedentary time are associated with increased colorectal cancer risk. The aim of this study is to evaluate these relationships in an Asian population. The Singapore Chinese Health Study enrolled 63 257 adults between 1993 and 1998. At enrollment, participants reported past year physical activity and time spent sitting. Incident colorectal cancers (n= 1994) were identified through 31 December 2014. Cox proportional hazards models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for potential confounders. Any strenuous-vigorous or moderate physical activity was reported by 13.7 and 22.1% of the cohort, respectively. Strenuous-vigorous physical activity was associated with statistically significant reduced colorectal cancer risk (HR= 0.85; 95% CI: 0.74-0.99 for >= 0.5 h/week vs. none), but moderate was not. In analysis stratified by time spent watching television, an inverse relationship between moderate physical activity and colorectal cancer risk (HR= 0.86; 95% CI: 0.72-1.01 for >= 0.5 h/week vs. none) was observed for those who reported at least 3 h/day sitting watching television (P-interaction=0.042). Participation in strenuous-vigorous physical activity, such as jogging, swimming, or heavy manual labor, was associated with reduced colorectal cancer risk among Singapore Chinese. Further research on physical activity and sedentary behaviors, independently and in combination, and colorectal cancer risk in Asian populations is needed. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.