Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells.
Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells.
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碱性成纤维细胞生长因子是在培养的视网膜色素上皮细胞中合成的。
DOI：
10.1016/0006-291x(87)90340-8
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发表时间：
1987
影响因子：
3.1
通讯作者：
Gospodarowicz,D
中科院分区：
文献类型：
--
作者：
Schweigerer,L;Malerstein,B;Neufeld,G;Gospodarowicz,D
来自牛视网膜色素上皮（RPE）的培养细胞表达碱性成纤维细胞生长因子（bFGF）基因，它们含有3.7和7.0 kb bFGF基因转录物，其分别翻译成Mr 17、500和18，000的免疫反应性bFGF。RPE细胞衍生的bFGF是生物活性的，即，它可以刺激毛细血管内皮细胞的增殖，并且细胞增殖的刺激被抗bFGF抗体阻断。我们认为，RPE细胞衍生的bFGF可能参与视网膜损伤后的修复机制，并在玻璃体内的假neoneoplastic增生受伤的RPE。
Cultured cells derived from bovine retinal pigment epithelium (RPE) express the basic fibroblast growth factor (bFGF) gene and they contain 3.7 and 7.0 kb bFGF gene transcripts which are translated into immunoreactive bFGF of Mr17,500 and 18,000, respectively. The RPE cell-derived bFGF is bioactive, i.e., it can stimulate the proliferation of capillary endothelial cells and the stimulation of cell proliferation is blocked by anti-bFGF antibodies. We suggest that RPE cell-derived bFGF may be involved in the repair mechanisms following retinal injury and in the intravitreal pseudoneoplastic proliferation of the injured RPE.