Toxoplasma gondii infection lower anxiety as measured in the plus-maze and social interaction tests in rats -: A behavioral analysis
Toxoplasma gondii infection lower anxiety as measured in the plus-maze and social interaction tests in rats -: A behavioral analysis
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DOI：
10.1016/j.bbr.2006.11.012
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发表时间：
2007-02-12
影响因子：
2.7
通讯作者：
Hernandez, Luis
中科院分区：
文献类型：
--
作者：
Gonzalez, Luis E.;Rojnik, Belen;Hernandez, Luis
有人认为，寄生虫弓形虫减少了啮齿动物对猫科掠食者的恐惧，这可能导致寄生虫通过增加生命周期数量来增加捕食和繁殖的速度。探讨T.弓形虫感染诱导了与焦虑相关的行为的选择性效应，Wistar大鼠腹腔内接种几种剂量的弓形虫。弓形虫速殖子和测试在两个动物测试的焦虑。在接种后的第三周，感染100和1000速殖子的大鼠以剂量相关的方式增加了十字迷宫开放臂探索。然而，无论是在社会互动水平或运动活动的措施没有检测到效果。接种后第七周，感染100个和1000个速殖子的大鼠表现出开放臂探索和社会调查增加，而任何运动活动测量均无变化。然而，感染较高剂量（1500个速殖子）的大鼠运动能力下降。这些数据支持T.弓形虫损害作为减少焦虑的功能的警告机制。寄生虫和宿主免疫反应的脑定殖模式表明，对边缘区的主要入侵是一种天然的抗焦虑机制。(c)2006 Elsevier B.V.保留所有权利。
It has been suggested that the parasite Toxoplasma gondii reduces the fear of rodents toward their feline predators, which may lead to an augmented rate of predation and multiplication of the parasite through an increased number of life cycles. To investigate whether T. gondii infection induces selective effects on behavior associated with anxiety, Wistar rats were inoculated i.p. with several doses of T. gondii tachyzoites and tested in two animal tests of anxiety. In the third week following inoculation, rats infected with 100 and 1000 tachyzoites increased plus-maze open arm exploration in a dose-related manner. However, no effect was detected in either social interaction levels or motor activity measures. In the seventh week after inoculation, rats infected with 100 and 1000 tachyzoites showed increased open arm exploration and social investigation without change on any motor activity measures. However, rats infected with a higher dose (1500 tachyzoites) showed a drop in locomotion. These data support the hypothesis that T. gondii impairs mechanism of warning as a function of reduced anxiety. The pattern of brain colonization by the parasite and the host immune response suggests that the predominant invasion to limbic areas works as a natural anxiolytic mechanism. (c) 2006 Elsevier B.V. All rights reserved.