Role of cyclinT/Cdk9 complex in basal and regulated transcription (review)
Role of cyclinT/Cdk9 complex in basal and regulated transcription (review)
复制标题
DOI：
10.3892/ijo.21.1.171
复制
发表时间：
2002-07-01
影响因子：
5.2
通讯作者：
Lania, L
中科院分区：
文献类型：
--
作者：
Napolitano, G;Majello, B;Lania, L
所有真核生物的细胞分裂和增殖都必须遵循一个遗传程序，称为细胞周期。为了确保通过细胞周期的适当进展，密切参与其调节的蛋白质必须在周期的适当窗口内周期性地表达。细胞周期蛋白和细胞周期蛋白依赖性激酶是细胞周期的核心时钟机制的模块组件。通过细胞周期的进展需要Cdks的激活。这些类别的激酶的活动受到积极和消极的因素，最重要的是干扰Cdk活动可能会导致肿瘤的发生。近年来，在将特异性细胞周期蛋白-Cdk激酶复合物与转录联系起来方面取得了一些进展。目前尚不清楚cyclin/Cdk复合物如何调节转录，最重要的是它们的底物是什么。这篇综述的目的是讨论我们目前对定义的细胞周期蛋白依赖性激酶的转录特性的分子机制的理解，特别强调细胞周期蛋白T/Cdk 9（P-TEFb）复合物，及其在细胞周期调控基因的调节中的作用。
Cell division and proliferation of all eukaryotics must follow a genetic program, termed the cell cycle. To ensure proper progression through the cell cycle, proteins that are intimately involved in its regulation must be periodically expressed within an appropriate window of the cycle. Cyclin and cyclin-dependent kinases are the modular components of the core clock machinery of the cell cycle. Progression through the cell cycle requires the activation of Cdks. The activities of these classes of kinases are tightly regulated by both positive and negative factors, and most importantly perturbation of Cdk activities can result in tumorigenesis. Progress has been made recently in connecting specific cyclin-Cdk kinase complexes and transcription. It is still unclear how cyclin/Cdk complexes regulate transcription, and most importantly what their substrates are. The aim of this review is to discuss our current understanding of the molecular mechanisms underlying the transcription properties of defined cyclin-dependent kinases, with a particular emphasis on the cyclin T/Cdk9 (P-TEFb) complex, and its role in the regulation of cell cycle controlling genes.