Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.
Exploring the prevalence and burden of sleep disturbance in primary brain tumor patients.
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探讨原发性脑肿瘤患者睡眠障碍的患病率和负担。
DOI：
10.1093/nop/npac049
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发表时间：
2022
影响因子：
2.7
通讯作者：
T
中科院分区：
文献类型：
--
作者：
King,AmandaL;Shuboni-Mulligan,DorelaD;Vera,Elizabeth;Crandon,Sonja;Acquaye,AlvinaA;Boris,Lisa;Burton,Eric;Choi,Anna;Christ,Alexa;Grajkowska,Ewa;Jammula,Varna;Leeper,HeatherE;Lollo,Nicole;Penas-Prado,Marta;Reyes,Jennifer;T
研究背景睡眠障碍（SD）在癌症患者中很常见，并与较差的临床结局相关。本横断面研究探讨了SD的患病率在原发性脑肿瘤（PBT）的人口，确定相关的人口统计学和临床特征，并调查了SD与其他症状和情绪disturbance.MethodsDemographic，临床特征，MD安德森症状量表，脑肿瘤，和患者报告的结果测量信息系统抑郁和焦虑的短形式收集PBT患者在研究进入。描述性统计，卡方检验，和独立检验被用来报告result.ResultsThe样本包括424例（58%男性，81%白人），平均年龄为49岁（范围18-81）和58%的高级别胶质瘤。19%的患者报告了中重度SD，与年龄较小、Karnofsky体能状态较差、MRI显示肿瘤进展和积极使用皮质类固醇相关。中重度SD患者的总体症状负担更高，报告的中重度症状更多。这些人还报告情感和情绪障碍领域的严重程度更高，抑郁和焦虑症状的患病率分别高出3至4倍。最常见的共同发生的症状与SD，嗜睡，和痛苦，虽然其他症状通常与肿瘤进展也经常共同occurred.ConclusionsPBT患者中重度SD更有症状，有更严重的情绪障碍，并有几个共同发生的症状。针对睡眠的干预可能会减轻其他并发症状，这可能会改善PBT患者的生活质量。未来的纵向工作检查客观和详细的主观睡眠报告，以及潜在的遗传风险因素，将是重要的。
BackgroundSleep disturbance (SD) is common in patients with cancer and has been associated with worse clinical outcomes. This cross-sectional study explored the prevalence of SD in a primary brain tumor (PBT) population, identified associated demographic and clinical characteristics, and investigated co-occurrence of SD with other symptoms and mood disturbance.MethodsDemographic, clinical characteristics, MD Anderson Symptom Inventory-Brain Tumor, and Patient Reported Outcome Measurement Information System Depression and Anxiety Short-Forms were collected from PBT patients at study entry. Descriptive statistics, Chi-square tests, and independentt-tests were used to report results.ResultsThe sample included 424 patients (58% male, 81% Caucasian) with a mean age of 49 years (range 18–81) and 58% with high-grade gliomas. Moderate-severe SD was reported in 19% of patients and was associated with younger age, poor Karnofsky Performance Status, tumor progression on MRI, and active corticosteroid use. Those with moderate-severe SD had higher overall symptom burden and reported more moderate-severe symptoms. These individuals also reported higher severity in affective and mood disturbance domains, with 3 to 4 times higher prevalence of depressive and anxiety symptoms, respectively. The most frequently co-occurring symptoms with SD were, drowsiness, and distress, though other symptoms typically associated with tumor progression also frequently co-occurred.ConclusionsPBT patients with moderate-severe SD are more symptomatic, have worse mood disturbance, and have several co-occurring symptoms. Targeting interventions for sleep could potentially alleviate other co-occurring symptoms, which may improve life quality for PBT patients. Future longitudinal work examining objective and detailed subjective sleep reports, as well as underlying genetic risk factors, will be important.