Leptin is inversely related to age at menarche in human females.
Leptin is inversely related to age at menarche in human females.
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DOI：
10.1210/jcem.82.10.4280
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发表时间：
1997-10
期刊：
影响因子：
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通讯作者：
V. Matkovic;J. Ilich;M. Skugor;N. E. Badenhop;P. Goel;A. Clairmont;D. Klisovic;Ramzi W. Nahhas;J. Landoll
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文献类型：
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作者：
V. Matkovic;J. Ilich;M. Skugor;N. E. Badenhop;P. Goel;A. Clairmont;D. Klisovic;Ramzi W. Nahhas;J. Landoll
在过去的世纪中，由于营养和身体肥胖，出现了月经初潮提前的趋势。随着肥胖基因及其产物瘦素的发现，我们从一个新的角度重新审视了这一假说。由于月经初潮延迟和消瘦被认为是骨质疏松的危险因素，我们还评估了瘦素与骨量的关系。对343名4岁以上青春期女性进行了体成分和血清瘦素水平的测定，并记录了月经初潮时间。身体成分测定双X射线吸收法，瘦素的一个新的RIA。所有参与者在基线时都是月经初潮前（年龄8.3-13.1岁）。瘦素与体脂（r = 0.81; P < 0.0001）和体脂变化（r = 0.58; P < 0.0001）密切相关。血清瘦素浓度升高至12.2 ng/mL（95%置信区间，7.2-16.7）与初潮年龄下降相关。血清瘦素每增加1 ng/mL，初潮年龄降低1个月。血清瘦素水平为12.2 ng/mL对应于相对体脂百分比为29.7%，体重指数为22.3，体脂为16.0 kg。体重增加1公斤，月经初潮时间缩短13天。瘦素与骨面积呈正相关（r = 0.307; P < 0.0001），与骨面积变化呈正相关（r = 0.274; P < 0.0001）。一个临界的血液瘦素水平是必要的，以触发妇女的生殖能力，这表明一个阈值效应。瘦素是脂肪组织和性腺之间的媒介。瘦素也可能通过影响骨膜来介导肥胖对骨量的影响。这可能对骨质疏松症和骨关节炎的发展有影响。
Over the last century there has been a trend toward an earlier onset of menarche attributed to better nutrition and body fatness. With the discovery of the obesity gene and its product, leptin, we reexamined this hypothesis from a new perspective. As delayed menarche and leanness are considered risk factors for osteoporosis, we also evaluated the relation between leptin and bone mass. Body composition and serum leptin levels were measured, and the timing of menarche was recorded in 343 pubertal females over 4 yr. Body composition was measured by dual x-ray absorptiometry, and leptin by a new RIA. All participants were premenarcheal at baseline (aged 8.3-13.1 yr). Leptin was strongly associated with body fat (r = 0.81; P < 0.0001) and change in body fat (r = 0.58; P < 0.0001). The rise in serum leptin concentration up to the level of 12.2 ng/mL (95% confidence interval, 7.2-16.7) was associated with the decline in age at menarche. An increase of 1 ng/mL in serum leptin lowered the age at menarche by 1 month. A serum leptin level of 12.2 ng/mL corresponded to a relative percent body fat of 29.7%, a body mass index of 22.3, and-body fat of 16.0 kg. A gain in body fat of 1 kg lowered the timing of menarche by 13 days. Leptin was positively related to bone area (r = 0.307; P < 0.0001) and change in bone area (r = 0.274; P < 0.0001). A critical blood leptin level is necessary to trigger reproductive ability in women, suggesting a threshold effect. Leptin is a mediator between adipose tissue and the gonads. Leptin may also mediate the effect of obesity on bone mass by influencing the periosteal envelope. This may have implications for the development of osteoporosis and osteoarthritis.